Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 12/7/2016 |
| Start Date: | August 2007 |
| End Date: | August 2016 |
A Phase 2, Open-label Study to Evaluate Safety and Tolerability, and to Explore the Efficacy, of Dosing Regimens of Intraarticular 4975 in Patients With Chronic Moderate to Severe Pain of the Knee Associated With Osteoarthritis
This study will evaluate dosing regimens of 4975 in terms of safety and tolerability when
delivered as an intra-articular injection in the knee. Secondary objectives will be to
explore the efficacy of 4975 in terms of onset, extent and duration of pain relief.
delivered as an intra-articular injection in the knee. Secondary objectives will be to
explore the efficacy of 4975 in terms of onset, extent and duration of pain relief.
This is a single site study. The study drug, 4975, will be administered in various dosing
regimens by intra-articular injection followed by an observation period of up to 12 weeks.
Pain in the treated knee will be assessed before, during and after administration of the
study drug.
regimens by intra-articular injection followed by an observation period of up to 12 weeks.
Pain in the treated knee will be assessed before, during and after administration of the
study drug.
Inclusion Criteria:
- Male or female patients aged 40 years or over.
- Body mass index (BMI) of 35 or less.
- History of OA of the knee for at least 1 year and has experienced pain in the target
area for at least six months.
- X-Ray of the target knee.
- Willing and able to complete the study procedures.
Exclusion Criteria:
- Female patients who are pregnant or lactating or who plan to get pregnant.
- Clinically significant form of joint disease other than OA.
- Medical condition that could adversely impact the patient's participation, safety or
affect the conduct of the study.
- Prior major trauma in the target knee or major surgeries such as partial or total
knee arthroplasty.
- Arthroscopic surgery on the target knee within 6 months.
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