Neuroimaging Studies of Depression in Parkinson's Disease

Depression is a common and potentially serious complication of Parkinson's disease (PD).
Studies show that approximately 40 percent of PD patients are depressed. There is evidence
that these patients have deficits in neuropsychological function relative to non-depressed
PD patients. Despite the widespread toll on emotional health posed by PD, few studies have
undertaken a comprehensive examination of the neural underpinnings of Parkinsonian
depression. In this project, we will compare depressed versus non-depressed Parkinson
patients to a sample of demographically-matched healthy controls using neuropsychological
assessment and magnetic resonance imaging (MRI). To investigate possible effects of
anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients
will be tested both off and on Parkinsonian medications.

Inclusion Criteria:

- right-handed

- willing/able to undergo magnetic resonance imaging (MRI)

Exclusion Criteria:

- history of neurological condition other than Parkinson's disease

- history of psychiatric condition other than depression

- history of substance abuse/dependence