Use of Sildenafil for Treatment of Urinary Incontinence

Aim: To determine the effect of sildenafil on urinary incontinence.

1. Episodes of urinary incontinence will be recorded using a 3 day bladder diary.

2. Quantitative assessment of urinary incontinence will be performed at baseline and after
treatment using a Pad Test.

3. Muscle strength will be assessed through use of a perineometer.

4. To evaluate macrocirculatory blood flow in pelvic organs, women will be assessed with
noninvasive imaging before and after randomization to sildenafil.

5. Secondary outcomes will include evaluation of muscle and vaginal mucosal thickness.

Inclusion Criteria:

- Postmenopausal females, 50-80 years of age, at the time of consent

- Have stress or mixed urinary incontinence, with at least 3 episodes/week

- Willing and able to comply with study procedures

- Willing and able to provide written informed consent

Exclusion Criteria:

- Significant heart, liver, kidney, pulmonary, blood, autoimmune or peripheral vascular
disease (history of Hashimoto's thyroiditis is not exclusionary if stable and thyroid
replacement is being administered. Thyroid testing will be performed at screening and
as needed during study visits. )

- Systolic blood pressure <100 or >150, diastolic blood pressure <60 or >90 after
repeated evaluation with proper cuff. This range is smaller than the acceptable range
stated in the prescribing information for sildenafil (>90/50 and <170/110)

- Diabetes mellitus or other untreated endocrine disease

- Active cancer

- Currently using and planning to continue use of urinary incontinence medications
during study period

- BMI > 40

- HIV, Hepatitis B, or Hepatitis C

- Use of systemic nitrates, anabolic steroids or corticosteroids in the past 6 months

- Use of alpha blockers

- Any medical condition that, in the opinion of the investigator, would place the
subject at increased risk for participation.

- Known allergic reaction to any agent under investigation or required by the protocol.

- History of prior non-compliance or the presence or history of psychiatric condition
(including drug or alcohol addiction) that would, in the opinion of the investigator,
make it difficult for the subject to comply with the study procedures or follow the
investigators instructions.

- Females who are pregnant or lactating.