Goal-directed Fluid Resuscitation in Acute Pancreatitis
| Status: | Terminated |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/10/2016 |
| Start Date: | March 2009 |
| End Date: | June 2010 |
A Randomized-controlled Trial of a Targeted Approach to Fluid Resuscitation in Acute Pancreatitis
Vigorous fluid resuscitation is currently believed to play a key role in reducing
complications associated with acute pancreatitis. However, aggressive fluid replacement can
be associated with complications such as pulmonary fluid sequestration. The purpose of this
study is to evaluate alternative approaches to early fluid resuscitation for patients with
acute pancreatitis.
complications associated with acute pancreatitis. However, aggressive fluid replacement can
be associated with complications such as pulmonary fluid sequestration. The purpose of this
study is to evaluate alternative approaches to early fluid resuscitation for patients with
acute pancreatitis.
Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to
standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis.
Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to
normal saline on systemic inflammation in acute pancreatitis.
standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis.
Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to
normal saline on systemic inflammation in acute pancreatitis.
Inclusion Criteria:
- acute pancreatitis diagnosed by at least 2 criteria
- adult patients at least 18 years of age
Exclusion Criteria:
- history of severe cardiovascular, respiratory, renal, hepatic or
hematologic/immunologic disease
- concurrent metabolic or physiologic derangement requiring specific fluid management
- pregnancy
- patients transferred from acute care hospital
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