Trial of Quetiapine in Anorexia Nervosa

Inclusion Criteria:

- Meet criteria for DSM-IV anorexia nervosa (restricting or binge-eating/purging types)

- At least 15% below ideal body weight

- Judged to be reliable to keep clinic visits and able to take all tests and
examinations required by the protocol and be able to understand and decide whether or
not to sign the Informed Consent.

Exclusion Criteria:

Subjects will not be included in the study who present with any of the following:

- Schizophrenia or schizoaffective disorder (DSM-IV)

- Any ECG abnormality considered clinically significant by the investigator

- Subjects with liver enzymes elevated two times or more above normal

- Other laboratory abnormalities considered clinically significant by the investigator
including laboratory deviations requiring acute medical intervention

- Pregnant women, women of childbearing potential not using medically accepted means of
contraception (abstinence, IUD, birth control pills, barrier devices or implanted
progesterone rods stabilized for at least three months), and lactating women

- Serious suicide risk

- Any medical condition that would preclude the outpatient treatment of anorexia
nervosa or the use of quetiapine

- Organic brain disease

- History of severe allergies

- Multiple adverse drug reactions or known allergy to quetiapine

- Use of neuroleptic medications (except benzodiazepines) within 7 days preceding
randomization

- History of alcohol or substance abuse disorder as defined in the DSM-IV within the
past 3 months.