Study To Evaluate Safety And Efficacy Of PF-06700841 In Subjects With Moderate To Severe Plaque Psoriasis
Status: | Completed |
---|---|
Conditions: | Psoriasis |
Therapuetic Areas: | Dermatology / Plastic Surgery |
Healthy: | No |
Age Range: | 18 - 75 |
Updated: | 3/31/2019 |
Start Date: | December 2016 |
End Date: | March 2018 |
A PHASE 2A, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-06700841 IN SUBJECTS WITH MODERATE TO SEVERE PLAQUE PSORIASIS
The purpose of this study is to determine whether PF-06700841 is safe and effective in the
treatment of chronic plaque psoriasis.
treatment of chronic plaque psoriasis.
Inclusion Criteria:
- Have had a diagnosis of plaque psoriasis (psoriasis vulgaris) for at least 6 months
prior to Baseline/Day 1 (prior to first dose of study drug)
- Have a PASI score of 12 or greater AND a PGA score of 3 ("moderate") or 4 ("severe")
at Baseline/Day 1 (prior to first dose of study drug)
- Have plaque-type psoriasis covering at least 10% of total body surface area (BSA) at
Baseline/Day 1 (prior to first dose of study drug)
- Considered by dermatologist investigator to be a candidate for systemic therapy or
phototherapy of psoriasis (either naïve or history of previous treatment)
Exclusion Criteria:
- Currently have non-plaque forms of psoriasis, eg, erythrodermic, guttate, or pustular
psoriasis, with the exception of nail psoriasis which is allowed
- Have evidence of skin conditions (eg, eczema) at the time of screening or baseline
visit that would interfere with the evaluation of psoriasis
- Cannot discontinue systemic therapies and/or topical therapies for the treatment of
psoriasis and cannot discontinue phototherapy (UVB or PUVA)
- Have previously been treated with Secukinumab (Cosentyx), and Ixekizumab (Taltz).
- Have taken Apremilast (Otezla) within 3 months of first dose of study drug.
- Have undergone treatment with tofacitinib within 3 months of first dose.
We found this trial at
31
sites
59 One Mile Road
East Windsor, New Jersey 08520
East Windsor, New Jersey 08520
609-443-4500
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6565 S. Yale Ave.
Tulsa, Oklahoma 74136
Tulsa, Oklahoma 74136
918-392-4550
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Anaheim Clinical Trials, LLC Anaheim Clinical Trials (ACT) is a research center of excellence for...
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Rockefeller University The Rockefeller University is a world-renowned center for research and graduate education in...
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Lynn Health Science Institute Our mission is to provide clinical trials research and health services...
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