Study To Assess The Efficacy And Safety Of Pf-06651600 In Subjects With Rheumatoid Arthritis With An Inadequate Response To Methotrexate
Status: | Completed |
---|---|
Conditions: | Arthritis, Rheumatoid Arthritis |
Therapuetic Areas: | Rheumatology |
Healthy: | No |
Age Range: | 18 - 75 |
Updated: | 12/6/2018 |
Start Date: | December 20, 2016 |
End Date: | December 12, 2017 |
A Phase 2a, Randomized, Double-blind, Parallel Group, Placebo-controlled, Multi-center Study To Assess The Efficacy And Safety Profile Of Pf-06651600 In Subjects With Moderate To Severe Active Rheumatoid Arthritis With An Inadequate Response To Methotrexate
This is an 8 week study to assess the efficacy and safety profile of PF-06651600 in
seropositive subjects with rheumatoid arthritis with an inadequate response to methotrexate
(up to approximately 50% of subjects may also have had an inadequate response to 1 anti-TNF
biologic).
seropositive subjects with rheumatoid arthritis with an inadequate response to methotrexate
(up to approximately 50% of subjects may also have had an inadequate response to 1 anti-TNF
biologic).
Inclusion Criteria
- Subjects between the ages of 18 and 75 years, inclusive
- Must have moderate-to-severe, active Rheumatoid Arthritis
- Must have had an inadequate response to Methotrexate
- Subjects may have received one approved TNF inhibiting biologic agent that was
inadequately effective and/or not tolerated
Exclusion Criteria
- Subjects with any acute or chronic infections or infection history
- Have acute or active chronic dermatological disorders prior to study start
- Any major illness/condition(s) or evidence of an unstable clinical condition that in
the judgment of the investigator would make the subject inappropriate for entry into
this study
- Known immunodeficiency disorder or a first degree relative with hereditary
immunodeficiency
- Any live (attenuated) vaccines or current routine household contact with anyone who
has received live (attenuated) vaccine
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