Neuroimaging of Donor Iron Deficient Study
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Iron Deficiency Anemia, Anemia |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 3/29/2019 |
| Start Date: | January 2017 |
| End Date: | December 2021 |
Neuroimaging of Donor Iron Deficient Study (DIDS)
This pilot study is designed to investigate (1) whether getting iron treatment affects iron
in the brain and (2) how getting iron treatment affects brain functions when it is performing
specific cognitive tasks. By cognitive tasks, it means tasks that involve perceiving,
representing, or assessing things. The specific cognitive tasks used here will involve tests
of memory and processing speed.
in the brain and (2) how getting iron treatment affects brain functions when it is performing
specific cognitive tasks. By cognitive tasks, it means tasks that involve perceiving,
representing, or assessing things. The specific cognitive tasks used here will involve tests
of memory and processing speed.
Iron, the most abundant metal in the brain, is vital for multiple cellular processes,
including neurotransmitter synthesis, neuron myelination, and mitochondrial function. In the
United States, of the donors who provided the ~15 million units of red blood cells that were
collected for transfusion, 69% were repeat donors. Although iron deficiency is surprisingly
prevalent in first-time donors, its prevalence is even higher in these particularly
altruistic frequent donors, (i.e., up to 49% and 66% of male and female repeat donors,
respectively), manifested as iron depletion or iron-deficient erythropoiesis. Iron deficiency
from blood donation is associated with fatigue, restless leg syndrome, decreased physical
endurance and work capacity, and impaired concentration, attention, and other neurocognitive
functions; however, these conclusions are not based on definitive studies and have not yet
changed blood donation policy. This study is to collect data through noninvasive procedures
routinely employed in clinical practice to better understand how iron treatment may affect
brain functions.
including neurotransmitter synthesis, neuron myelination, and mitochondrial function. In the
United States, of the donors who provided the ~15 million units of red blood cells that were
collected for transfusion, 69% were repeat donors. Although iron deficiency is surprisingly
prevalent in first-time donors, its prevalence is even higher in these particularly
altruistic frequent donors, (i.e., up to 49% and 66% of male and female repeat donors,
respectively), manifested as iron depletion or iron-deficient erythropoiesis. Iron deficiency
from blood donation is associated with fatigue, restless leg syndrome, decreased physical
endurance and work capacity, and impaired concentration, attention, and other neurocognitive
functions; however, these conclusions are not based on definitive studies and have not yet
changed blood donation policy. This study is to collect data through noninvasive procedures
routinely employed in clinical practice to better understand how iron treatment may affect
brain functions.
Inclusion Criteria:
- Current participant of the associated randomized controlled trial conducted at
Columbia University Medical Center (therefore invited to participate in this optional
ancillary study).
Exclusion Criteria:
- Not a current participant of the associated randomized controlled trial conducted at
Columbia University Medical Center.
We found this trial at
1
site
630 W 168th St
New York, New York
New York, New York
212-305-2862
Principal Investigator: Eldad Hod, MD
Phone: 212-342-5648
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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