Reducing Colorectal Cancer Death Through Mailed Outreach Screening

This study seeks to establish the foundation to systematically study and improve the delivery
and effectiveness of colorectal cancer (CRC) screening in the VA by developing, implementing
and disseminating a pilot mailed-FIT screening outreach program that does not rely on having
a clinical office visit. The investigators specifically address the need to identify and
remediate potential failures to identify and offer screening to eligible Veterans through
multilevel interventions. The investigators will also create electronic data linkages to, in
future studies, enable evaluation of FIT performance characteristics and help close critical
evidence gaps for optimizing screening among Veterans. As this is a pilot study, the focus is
to assess feasibility of a population-based screening outreach approach through the
development, implementation and dissemination of a mailed FIT outreach program in the
Philadelphia VA Medical Center that does not rely on having an office visit.

Inclusion Criteria:

- The pragmatic trial will include Veterans in southeastern Pennsylvania and Southern
New Jersey who, during the funding year

- 50 to 75 years old

- Have received care at the Philadelphia VA Medical Center in the 18-48 months prior to
selection for the study but who have not been seen by primary care in the past 18
months prior to selection

- Due for screening

- Are asymptomatic for CRC

- This includes the period during which 3-sample testing was being regularly used at the
Philadelphia VA Medical Center

Exclusion Criteria:

- Have any known gastrointestinal symptoms such as:

- bleeding

- unexplained weight loss

- change in bowel habits

- family history of CRC

- inflammatory bowel disease (IBD)

- colectomy using International Classification of Disease (9th and 10th edition)
diagnostic code or by self-report.

- The investigators will also exclude Veterans:

- with evidence of prior colonoscopy within 10 years

- sigmoidoscopy within 5 years

- fecal occult blood test (FOBT)/FIT in the same calendar year

- The information used to exclude patients will be derived from the electronic queries
or chart audits.