Estrogen and Gender Biased Autoimmunity
| Status: | Completed |
|---|---|
| Conditions: | Lupus, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/2/2016 |
| Start Date: | April 2005 |
| End Date: | December 2013 |
| Contact: | Nabih I Abdou, MD, PhD. |
| Email: | niabdou@centerforrheumatic.com |
| Phone: | 816-531-0930 |
Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus
This study involves research to investigate how estrogen affects women of childbearing age
and its correlation to Systemic Lupus Erythematosus. The findings from this study might help
determine how body cells, called T Cells, react to estrogen. The study will seek to
determine if cells from women with Lupus, react differently from cells in persons without
Lupus. We will attempt to identify genetic factors that determine the effects of estrogen on
Lupus cells.
and its correlation to Systemic Lupus Erythematosus. The findings from this study might help
determine how body cells, called T Cells, react to estrogen. The study will seek to
determine if cells from women with Lupus, react differently from cells in persons without
Lupus. We will attempt to identify genetic factors that determine the effects of estrogen on
Lupus cells.
This is a 3-year study. The total number of subjects enrolled will depend on the results
obtained. The subjects will be at least 18 years of age and pre-menopausal. Exclusion to
include pregnant women, and all subjects are told not to get pregnant while on study. Also,
they cannot take hormones by mouth or patch while on study. The study can include healthy
subjects as well. Blood will be drawn (120 ml) four times a year, randomly.
obtained. The subjects will be at least 18 years of age and pre-menopausal. Exclusion to
include pregnant women, and all subjects are told not to get pregnant while on study. Also,
they cannot take hormones by mouth or patch while on study. The study can include healthy
subjects as well. Blood will be drawn (120 ml) four times a year, randomly.
Inclusion Criteria:
- female subjects with Lupus, and female subjects without Lupus. age at least 18, not
pregnant and not planning to get pregnant.
Exclusion Criteria:
- Pregnant or planning to get pregnant. On hormone replacement, or birth control of any
kind.
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