An Investigational Immuno-therapy Study for Safety of Nivolumab in Combination With Ipilimumab to Treat Advanced Cancers



Status:Recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/16/2018
Start Date:September 14, 2016
End Date:November 17, 2021
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3b/4 Safety Trial of Flat Dose Nivolumab In Combination With Ipilimumab in Participants With Non-Small Cell Lung Cancer

A study to evaluate the safety of Nivolumab given in combination with Ipilimumab in patients
with advanced cancers. The initial group will enroll patients with newly diagnosed Stage 4 or
non-small cell lung cancer that has come back.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologically confirmed Stage 4 or recurrent non-small cell lung cancer

- Eastern Cooperative Oncology Group (ECOG) score 0-1 (Physically able to carry out
light housework or office work through to being fully active as you were before
cancer)

- No prior systemic anticancer therapy (including EGFR and ALK inhibitors)

- Tissue or Programmed death-ligand 1 (PD-L1) results available

Cohort 1A Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) score 2 or

- Eastern Cooperative Oncology Group (ECOG) score 0-1 and one disease specific criteria
as listed in the protocol

Cohort C Inclusion Criteria:

- High Tumor Mutation Burden

Exclusion Criteria:

- Untreated brain metastases

- An active malignancy that requires concurrent intervention

- Active, known or suspected autoimmune disease

- Carcinomatous meningitis, which means there is inflammation of the covering of the
brain, caused by cancer

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
71
sites
MetroHealth Med Ctr
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
Phone: 216-778-4568
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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Memorial Cancer Institute
3700 Johnson Street
Hollywood, Florida 33021
Phone: 310-206-0179
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Hollywood, FL
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University of Arkansas for Medical Sciences
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
Phone: 501-686-8274
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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Central Coast Medical Oncology Corporation
220 S Palisade Dr # 204
Santa Maria, California 93454
Phone: 310-206-0179
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Santa Maria, CA
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Lehigh Valley Health Network
Allentown, Pennsylvania 18105
Phone: 610-402-1642
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University Cancer and Blood Center LLC
Athens, Georgia 30607
Phone: 706-353-2990
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Athens, GA
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Winship Cancer Institute
Atlanta, Georgia 30322
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Northside Hospital
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Phone: 770-496-9457
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Atlanta, GA
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Texas Oncology, PA at South Austin Cancer Center
Austin, Texas 78745
Phone: 512-447-2202
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Austin, TX
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CBCC Global Research
6501 Truxtun Avenue
Bakersfield, California 93309
Phone: 310-206-0179
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Essex Oncology of North Jersey
Belleville, New Jersey 07109
Phone: 973-751-8880
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Local Institution
Berkeley, California 94704
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Alabama Oncology
Birmingham, Alabama 35223
Phone: 205-263-9746
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Local Institution
Boise, Idaho 83712
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Local Institution
Bronx, New York 10467
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Instituto Medico Especializado Alexander Fleming
Capital Federal, Buenos Aires
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Local Institution
Chandler, Arizona 85224
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Charleston Hematology/Oncology Associates, Pa
Charleston, South Carolina 29403
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Tennessee Oncology PLLC
Chattanooga, Tennessee 37404
Phone: 877-691-7274
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Oncology Hematology Care
5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Phone: 513-751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
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Maryland Oncology Hematology PA
Columbia, Maryland 21044
Phone: 410-964-2212
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Columbia, MD
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Local Institution
Corvallis, Oregon 97330
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Texas Oncology, PA
Dallas, Texas 75246
Phone: 214-265-2080
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Rocky Mountain Cancer Center
Denver, Colorado 80218
Phone: 303-388-4876
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DUMC
Durham, North Carolina 27710
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Minnesota Oncology Hematology, PA
Edina, Minnesota 55435
Phone: 612-884-6300
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Edina, MN
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Providence Regional Cancer Partnership
1717 13th St
Everett, Washington 98201
(425) 297-5500
Providence Regional Cancer Partnership Founded in 2007, the Providence Regional Cancer Partnership is the result...
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Everett, WA
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-208-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Texas Oncology-Fort Worth 12th Ave.
Fort Worth, Texas 76104
Phone: 817-850-2011
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St. Francis Cancer Treatment Center
Grand Island, Nebraska 68803
Phone: 308-398-6518
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St. Mary's Hospital Regional Cancer Center
Grand Junction, Colorado 81501
Phone: 310-206-0179
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Marin Cancer Care, Inc.
Greenbrae, California 94904
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Local Institution
Hot Springs, Arkansas 71913
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Local Institution
Indianapolis, Indiana 46260
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Jackson Oncology Associates
Jackson, Mississippi 39202
Phone: 601-974-5547
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Cancer Specialists Of North Fl
Jacksonville, Florida 32256
Phone: 904-363-7462
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Local Institution
La Jolla, California 92093
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Local Institution
Langhorne, Pennsylvania 19047
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Phone: 702-952-3400
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Kentucky One Health St. Joseph East Cancer Center
150 North Eagle Creek Drive
Lexington, Kentucky 40509
Phone: 720-874-1346
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Lexington, KY
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Saint Barnabas Medical Cancer Center
94 Old Short Hills Road
Livingston, New Jersey 07039
Phone: 973-322-5325
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Texas Oncology - Longview
Longview, Texas 75601
Phone: 903-579-9800
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Los Angeles Hematology/Oncology Medical Group
Los Angeles, California 90017
Phone: 213-977-1214
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UCLA
Los Angeles, California 90095
(310) 825-4321
Phone: 310-206-8309
UCLA UCLA's primary purpose as a public research university is the creation, dissemination, preservation and...
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Local Institution
Macon, Georgia 31201
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Local Institution
Morristown, New Jersey
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Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 877-691-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Illinois Cancer Specialists
Niles, Illinois 60714
Phone: 847-827-9060
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Florida Cancer Affiliates - Ocala
433 Southwest 10th Street
Ocala, Florida 34471
Phone: 352-732-4938
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Local Institution
Oklahoma City, Oklahoma 73103
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Arizona Oncology Assoc, Pc-Hal
Phoenix, Arizona 85016
Phone: 928-204-4198
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Allegheny Health Network
PIttsburgh, Pennsylvania 15212
Phone: 412-235-1316
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Local Institution
Pittsburgh, Pennsylvania 15240
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Texas Oncology-Plano East
Plano, Texas 75075
Phone: 972-867-3577
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Local Institution
Portland, Oregon 97201
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Torrance Health Association
Redondo Beach, California 90277
Phone: 310-750-3376
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Cancer Care Specialists
Reno, Nevada 89511
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Valley Medical Center
Renton, Washington 98055
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Virginia Cancer Institute
Richmond, Virginia 23235
Phone: 804-288-7159
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Local Institution
San Diego, California 92123
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Coastal Integrative Cancer Care
San Luis Obispo, California 93401
Phone: 310-206-0179
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Guthrie Medical Group, PC
Sayre, Pennsylvania 18840
Phone: 570-887-2141
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Local Institution
Skokie, Illinois 60077
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Medical Oncology Associates
Spokane, Washington 99208
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Willamette Valley Cancer Center
Springfield, Oregon 97477
Phone: 541-988-0656
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Springfield, OR
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Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
Phone: 530-582-6438
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Arizona Oncol Assoc Dba (Hem Onc Physicians&Extenders) Hope
Tucson, Arizona 85704
Phone: 520-797-4468
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Texas Oncology Cancer Care And Research Center
Waco, Texas 76712
Phone: 254-399-0741
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Innovative Clinical Research Institute, LLC
Whittier, California 90603
Phone: 562-693-4477
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Cancer Center of Kansas
818 N. Emporia, #403
Wichita, Kansas 67214
(316) 262-4467
Phone: 316-262-4467
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
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Wake Forest Baptist Health
Winston-Salem, North Carolina 27157
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