Fentanyl Sublingual Spray for the Treatment of Moderate to Severe Post-Operative Pain

Inclusion Criteria:

- Meets protocol-specified criteria for qualification and contraception

- Willing and able to remain confined in the study unit for the entire duration of each
treatment period and comply with restrictions related to food, drink and medications

- Voluntarily consents to participate and provides written informed consent prior to any
protocol-specific procedures

Exclusion Criteria:

- History or current use of over-the-counter medications, dietary supplements, or drugs
(including nicotine and alcohol) outside protocol-specified parameters

- Signs, symptoms or history of any condition that, per protocol or in the opinion of
the investigator, might compromise:

1. the safety or well-being of the participant or study staff;

2. the safety or well-being of the participant's offspring (such as through
pregnancy or breast-feeding);

3. the analysis of results