Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any - 3 |
| Updated: | 2/1/2019 |
| Start Date: | October 15, 2016 |
| End Date: | June 15, 2017 |
This study will estimate the incidence of hypothyroidism in a pediatric population of
children under age 4, based on data from the US-based Kaiser Permanente Northern California
database, which were exposed to iodinated contrast agent through having a diagnostic
procedure.
children under age 4, based on data from the US-based Kaiser Permanente Northern California
database, which were exposed to iodinated contrast agent through having a diagnostic
procedure.
Inclusion Criteria:
- Children under age 4 in the Kaiser Permanente Northern California (KPNC) database, who
had a diagnostic procedure with an iodinated contrast agent.
- Participants should be member of the KPNC for at least 3 months before the iodinated
contrast exposure, except where the child is under 3 months of age at time of initial
exposure, and 2 weeks after the exposure.
Exclusion Criteria:
- Diagnosis of hypothyroid any time prior to the iodine contrast exposure.
- Lab values for low thyroid (TSH > 5 mU/L for children) any time before the exposure
- Thyroid replacement therapy, Hashimoto thyroiditis, or congenital hypothyroidism any
time prior to exposure.
We found this trial at
1
site
