Assessing Deformable Image Registration in the Lung Using Hyperpolarized-gas MRI
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 64 |
| Updated: | 10/26/2017 |
| Start Date: | July 2016 |
| End Date: | July 2018 |
| Contact: | Rachel Dieterich, RN |
| Email: | rrd8w@virginia.edu |
| Phone: | 434-243-6074 |
Assessing Deformable Image Registration in the Lung Using Hyperpolarized-gas
Recently, the investigators have demonstrated a novel hyperpolarized helium tagging Magnetic
Resonance Image (MRI) technique that is capable of directly, in vivo, and non-invasively
measuring physiological lung deformation on a regional basis. This unique imaging technique
holds great promise for assessing, validating, and improving the use of Deformable image
Registration (DIR) algorithms in the lung. Our long term aim is to apply hyperpolarized gas
tagging MRI to study lung biomechanics, develop more physiologically sound DIR algorithms for
the lungs, and eventually improve radiotherapy of lung cancer. The overall aim of this
application is to optimize the hyperpolarized helium tagging MRI technology and establish its
usefulness for DIR assessment.
Our first objective is to develop and optimize a methodology based on 3 Dimensional (3D)
hyperpolarized helium tagging MRI of healthy subjects, for directly measuring lung
deformation between inhalation and exhalation. Our second objective is to develop
physiologically sound digital thorax phantoms based on helium-3 tagging MRI of healthy
subjects and demonstrate their use for DIR assessment in the lung. These phantoms will be
used to evaluate a range different DIR algorithms, by comparing the errors between the
DIR-derived deformation vector fields and the ground truth represented in the digital
phantom. Successful completion of these aims will yield a novel methodology for DIR
assessment in the lung for radiotherapy.
Resonance Image (MRI) technique that is capable of directly, in vivo, and non-invasively
measuring physiological lung deformation on a regional basis. This unique imaging technique
holds great promise for assessing, validating, and improving the use of Deformable image
Registration (DIR) algorithms in the lung. Our long term aim is to apply hyperpolarized gas
tagging MRI to study lung biomechanics, develop more physiologically sound DIR algorithms for
the lungs, and eventually improve radiotherapy of lung cancer. The overall aim of this
application is to optimize the hyperpolarized helium tagging MRI technology and establish its
usefulness for DIR assessment.
Our first objective is to develop and optimize a methodology based on 3 Dimensional (3D)
hyperpolarized helium tagging MRI of healthy subjects, for directly measuring lung
deformation between inhalation and exhalation. Our second objective is to develop
physiologically sound digital thorax phantoms based on helium-3 tagging MRI of healthy
subjects and demonstrate their use for DIR assessment in the lung. These phantoms will be
used to evaluate a range different DIR algorithms, by comparing the errors between the
DIR-derived deformation vector fields and the ground truth represented in the digital
phantom. Successful completion of these aims will yield a novel methodology for DIR
assessment in the lung for radiotherapy.
Inclusion Criteria:
- All subjects must be willing to participate and undergo the procedure, and be
manageable as out-patients.
- Normal Subjects: Currently feeling well without respiratory symptoms.
- No history of lung disease.
- Never personally smoked (defined as less 100 cigarettes in their lifetime).
-Secondhand smoke exposure is not an exclusion criterion.
Exclusion Criteria:
- Blood oxygen saturation of less than 92% as measured by pulse oximetry on the day of
imaging.
- FEV1 percent predicted less than 80%.
- Pregnancy or lactation.
- Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign
bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any
implanted device that cannot be verified as MRI compliant will be excluded.
- Chest circumference greater than that of the xenon MR and/or helium coil. The
circumference of the coil is approximately 42 inches.
- History of congenital cardiac disease, chronic renal failure, or cirrhosis.
- Inability to understand simple instructions or to hold still for approximately 10
seconds.
- History of respiratory infection within 2 weeks prior to the MR scan
- History of MI, stroke and/or poorly controlled hypertension.
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