Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

The primary study aim is to determine whether fluoxetine + CBT is a more effective treatment
than placebo + CBT for substance outcomes, depression, and behavior problems. The current
community standard of care often withholds pharmacotherapy for depression in substance
abusing adolescents, since it is often assumed that their depressions may remit with SUD
treatment alone. However, this is an untested hypothesis in adolescents and one that we
propose to test in the current study.

Inclusion Criteria:

- Must have DSM IV non bipolar Major Depressive disorder (by clinical interview), DSM
IV Conduct Disorder, and Non-Tobacco Substance Disorder.

Exclusion Criteria:

- History of or current psychosis, history of psychotic depression, bipolar disorder I
or II, family history of first degree relative with bipolar I, lifetime history of
non-substance induced Mania/Hypomania

- Unstable chronic or serious medical illness

- Currently pregnant

- Take psychotrophic medication, past 2 months: medication or treatment for depression,
clinically significant laboratory abnormality