Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism

Inclusion Criteria:

1. An understanding, ability, and willingness to fully comply with study procedures and
restrictions.

2. Ability to voluntarily provide written, signed, and dated informed consent as
applicable to participate in the study.

3. Adult men or women aged greater than or equal (>=) 18 years at the time of consent.
The date of participant signature of the informed consent is defined as the beginning
of the Screening Period. The Screening Period for this study may encompass both the
Administrative Screening Period (if needed) and the Clinical Screening Period. For
purposes of this inclusion criterion, age will only be assessed at the time the
informed consent is first signed by the study participant.

4. History of hypoparathyroidism for >=12 months, post-diagnosis, inclusive of historical
biochemical evidence of hypocalcemia with concomitant serum intact parathyroid hormone
(PTH) concentrations below the lower limit of the laboratory normal range.

5. Requirement for supplemental oral calcium treatment >=1000 milligrams (mg) elemental
calcium per day.

6. Requirement for therapy with active forms of vitamin D at a minimum dose of >=0.25
microgram (mcg) per day (that is, >=0.25 mcg calcitriol or equivalent per day).

7. Serum calcium level within the laboratory normal reference range based on clinical
chemistry lab results at the Clinical Screening Visit (based on central and/or local
lab results) and Treatment Period 1, Day -2 (based on central and/or local lab
results), or if outside of normal range, considered not clinically significant by the
investigator.

8. Urinary calcium excretion >=200mg (5 millimolar [mmol])/24 hour (h), based on a
24-hour collection, collected anytime during the Clinical Screening Period, but prior
to check-in to the Clinical Research Center (CRC) at Treatment Period 1, Day -2 (based
on central and/or local lab results).

9. Serum magnesium level within the laboratory normal range at the Clinical Screening
Visit or, if outside of normal range, considered not clinically significant by the
investigator.

10. Serum thyroid function tests within normal laboratory limits at the Clinical Screening
Visit, or, if outside of normal range, considered as not clinically significant by the
investigator.

11. Serum 25-hydroxyvitamin D (25(OH)D) level between the lower limit of normal and
1.5-fold the laboratory upper limit of normal, or, if outside of this range,
considered not clinically significant by the investigator, at the Clinical Screening
Visit.

12. Serum creatinine less than (<) 1.5 mg/ decilitre (dL) (<133 micromole [mmol]/ litre
[L]) AND estimated creatinine clearance greater than (>) 60 millilitre (mL)/minute
(>1.002mL/ Second [s]) at the Clinical Screening Visit, and serum creatinine <1.5
mg/dL (<133mmol/L) at Treatment Period 1, Day -2.

13. Male or non-pregnant, non-lactating female who agrees to comply with any applicable
contraceptive requirements of the protocol or females of non-childbearing potential.

Exclusion Criteria:

1. Participation in any other investigational drug study in which the last dose of
investigational drug occurred within 3 months prior to Day 1 of Treatment Period 1 (or
within 5 half-lives, if elimination half-life is greater than 18 days).

2. Presence or history of a clinically significant disorder involving the cardiovascular,
respiratory, renal, gastrointestinal, immunologic, hematologic, endocrine (with
exception of the condition under study), or neurologic system(s) or psychiatric
disease as determined by the investigator.

3. Known history of hypoparathyroidism resulting from an activation mutation in the
calcium sensing receptor (CaSR) gene or impaired responsiveness to PTH
(pseudohypoparathyroidism).

4. Any disease that might affect calcium metabolism or calcium-phosphate homeostasis
other than hypoparathyroidism, including but not limited to, active hyperthyroidism;
poorly controlled insulin-dependent diabetes mellitus or type 2 diabetes mellitus;
severe and chronic cardiac, liver or renal disease; Cushing's syndrome; neuromuscular
disease such as rheumatoid arthritis; myeloma; pancreatitis; malnutrition; rickets;
recent prolonged immobility; active malignancy, bone metastases or a history of
skeletal malignancies; primary or secondary hyperparathyroidism; a history of
parathyroid carcinoma; hypopituitarism, acromegaly; or multiple endocrine neoplasia
types 1 and 2, as determined by the investigator.

5 . In male and female rats, parathyroid hormone caused an increase in the incidence of
osteosarcoma (a malignant bone tumor). The occurrence of osteosarcoma was dependent on
parathyroid hormone dose and treatment duration. This effect was observed at parathyroid
hormone exposure levels ranging from 3 to 71 times the exposure levels in humans receiving
a 100 mcg dose of rhPTH(1-84). Therefore, participant who are at increased baseline risk
for osteosarcoma such as participant with Paget's disease of bone or unexplained elevations
of alkaline phosphatase, pediatric and young adult participants with open epiphyses,
participants with hereditary disorders predisposing to osteosarcoma or participant with a
prior history of external beam or implant radiation therapy involving the skeleton are
excluded.

6. Participants who have a known history of hypercalcemia during initiation of treatment
with PTH, PTH analogues or fragments of PTH.

7. Participants who have a known history of hypocalcemia following abrupt withdrawal of
treatment with PTH, PTH analogues or fragments of PTH.

8. Participant dependent on regular parenteral calcium infusions (example, calcium
gluconate) to maintain calcium homeostasis within 3 months prior to enrollment, as
determined by the investigator.

9. Use of the following medications prior to administration of investigational product
within: 14 days- thiazide diuretics; 30 days - loop diuretics, lithium, systemic
corticosteroids (medical judgment is required by the investigator. Primarily high doses of
systemic corticosteroids [example, prednisone] should be excluded. Stable doses of
hydrocortisone [example, as treatment for Addison's disease] may be acceptable); 3 months -
calcitonin, cinacalcet hydrochloride, treatment with rhPTH(1-84) or N-terminal PTH or
PTH-related peptide fragments or analogs; For females: changes in hormone replacement
therapy within 3 months are excluded. Stable (>=3 months) hormone replacement therapy is
acceptable; 6 months - fluoride tablets, oral bisphosphonates, methotrexate, growth
hormone, digoxin, raloxifene or similar selective estrogen receptor modulators (SERMs); 12
months - intravenous bisphosphonates, drug or alcohol abuse, as determined by the
investigator.

10. Presence of any clinically significant results from laboratory tests, vital signs
assessments, or electrocardiograms (ECGs), as judged by the investigator.

11. Twelve-lead ECG values (average of triplicate readings) demonstrating QTc>450
millisecond (msec) (males) or >470 msec (females) at the Clinical Screening Visit and/or
any time points up to and including predose of Day 1 (Period 1).

12. Any medical condition or prior therapy that, in the opinion of the investigator, would
make the participant unsuitable for this study.

13. Positive test result for any of the following viral infections at the Clinical
Screening Visit: Hepatitis B surface antigen; hepatitis C; human immunodeficiency virus
(HIV) 14. Known significant bleeding diathesis that could preclude multiple venipunctures
as determined by the investigator.

15. Participants who have donated a total of 100 mL to 499 mL of whole blood within 30 days
prior to dosing, or participants who have donated a total of more than 499 mL of whole
blood within 56 days prior to dosing.

16. A positive screen for drugs of abuse at the Clinical Screening Visit, and/or a positive
screen for drugs of abuse and alcohol at check-in to the CRC at Treatment Period 1.
Participants taking prescription medications that might be detected during the urine screen
for drugs of abuse may be enrolled per the investigator's medical judgment.

17. History of a clinically significant illness during the 4 weeks prior to dosing (as
determined by the investigator).

18. History of any clinically significant surgery or procedure within the past 8 weeks, as
determined by the investigator.

19. History of an allergic response(s) to PTH or PTH analogs, or other clinically
significant allergies, as determined by the investigator.