A Treatment for Severe Inflammatory Acne Subjects

Key Inclusion Criteria:

1. Male or female subjects, 12 years of age or older at Screening visit.

2. Subjects with a clinical diagnosis of severe inflammatory acne (IGA score of 4).

3. Subjects with 4 or fewer nodules or cysts > 1 cm in diameter on the face.

4. Subjects 18 years of age or older must read and sign the Informed Consent Form, which
includes Photography Consent and HIPAA authorization, prior to any participation in
the study. Consent will be obtained prior to any study-related procedures. Subjects
under the age of 18 years must sign an Assent to Participate Form to participate in
the study and must have one parent or guardian read and sign the Informed Consent Form
prior to any study-related procedure. (The parent or guardian is not required to
attend the following visits unless requested.)

Key Exclusion Criteria:

1. Subjects with nodulocystic or conglobate acne, acne fulminans, or secondary acne
(chloracne, drug-induced acne, etc.).

2. Subjects with 5 or more acne nodules or cysts > 1 cm in diameter on the face at
Screening and Baseline visits.

3. Female subjects who are pregnant, nursing, or planning a pregnancy during the study.

4. Subjects who have used any systemic therapy directed at improving acne, including
antibiotics, within 30 days prior to Baseline visit.

5. Subjects who are at risk in terms of precautions, warnings, and contraindications for
the investigational study drugs (see Appendix 14.1 for package inserts for adapalene
0.3%/benzoyl peroxide 2.5% gel and doxycycline hyclate Tablets).

6. Subjects with any other condition or circumstance which, in the Investigator's
opinion, may put the subject at risk (e.g., a history of significant renal disease
with impairment of renal function), confound the study results, or interfere with the
subject's participation in the study.

7. Sponsor and study site staff, relatives of staff members, or other individuals who
would have access to the clinical study protocol.