Microbiome, Antibiotics, and Growth Infant Cohort
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/16/2019 |
| Start Date: | December 2016 |
| End Date: | July 2021 |
| Contact: | Jeffrey S Gerber, MD, PhD |
| Email: | gerberj@email.chop.edu |
| Phone: | 267-426-8775 |
Early Life Antibiotics, Gut Microbiome Development, and Risk of Childhood Obesity
This cross-disciplinary study will assemble and longitudinally follow a large, diverse birth
cohort to determine the relationships between early life antibiotic exposure, microbiome
development, growth, antibodies, and immunostimulation.
cohort to determine the relationships between early life antibiotic exposure, microbiome
development, growth, antibodies, and immunostimulation.
Perinatal and infant antibiotic exposures are common and have been linked to changes in the
gut microbiome, which plays a central role in health and disease. Childhood obesity is an
epidemic and animal models have linked antibiotic induced changes in the microbiome with
increased adiposity. Infants become colonized with trillions of bacteria in the first few
hours of life. During this time period, their nascent immune system develops tolerance to
commensal microbes
The primary objectives are to measure the impact of common perinatal and early childhood
antibiotic exposures on the structure and function of the developing gut microbiome. To
determine the association between common perinatal and early childhood antibiotic exposures
and weight/adiposity gain in a large birth cohort of children. To determine mechanisms for
the association between microbiome changes over time and the rate of weight/adiposity gain in
a large birth cohort of children. To determine the normal developmental pattern by which
healthy children develop antibodies in their blood against the microbes that naturally
colonize their intestines. To determine the association between immunostimulation and
protection from persistent colonization in humans.
gut microbiome, which plays a central role in health and disease. Childhood obesity is an
epidemic and animal models have linked antibiotic induced changes in the microbiome with
increased adiposity. Infants become colonized with trillions of bacteria in the first few
hours of life. During this time period, their nascent immune system develops tolerance to
commensal microbes
The primary objectives are to measure the impact of common perinatal and early childhood
antibiotic exposures on the structure and function of the developing gut microbiome. To
determine the association between common perinatal and early childhood antibiotic exposures
and weight/adiposity gain in a large birth cohort of children. To determine mechanisms for
the association between microbiome changes over time and the rate of weight/adiposity gain in
a large birth cohort of children. To determine the normal developmental pattern by which
healthy children develop antibodies in their blood against the microbes that naturally
colonize their intestines. To determine the association between immunostimulation and
protection from persistent colonization in humans.
Inclusion Criteria:
- Born at Pennsylvania Hospital
- Recruited at < 120 hours of age
- Born at 36 0/7 weeks gestation
- Birth weight ≥ 2000 grams
- Parents plan to receive well-child care in the Children's Hospital of Philadelphia
(CHOP) network, Society Hill Pediatrics, Center City Pediatrics, Penn Medicine or
South Philly Pediatrics
- Biological mother is the legal guardian, or the child is born from a surrogacy with
guardianship immediately transferred in hospital
Exclusion Criteria:
- Child in neonatal intensive care unit (NICU) for ≥ 120 cumulative hours
- Biological mother NOT legal guardian
- Biological mother NOT primary caretaker
- Biological mother < 18 years of age
- Child has culture confirmed-infection
- Biological mother is non-English speaking
We found this trial at
1
site
South 34th Street
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
215-590-1000
Principal Investigator: Jeffrey S Gerber, MD, PhD
Phone: 267-426-8775
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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