Expanded Access With ABT-888 (Veliparib) to Treat Metastatic Breast Cancer

ABT-888 (Veliparib) or Poly(ADP-ribose)-polymerase (PARP) is a nuclear enzyme that recognizes
deoxyribonucleic acid (DNA) damage and facilitates DNA repair. Inactive PARPs 1 and 2 bind to
damaged DNA, which leads to their auto-activation. The resulting activated PARP then
poly(ADP-ribosyl)ates many nuclear target proteins, including those that facilitate DNA
repair of both single-stranded or double-stranded DNA breaks. Thus, PARP inhibition will
result in less efficient DNA repair following a DNA damage insult.

Since cancer cells are genetically unstable, often exhibiting complex karyotypes that include
large deletions, insertions, and unbalanced translocations of chromosomal fragment, these
cells are more susceptible than normal tissues to cytotoxicity induced by DNA-damaging
agents.Of these, deficiencies in mismatch repair and homologous recombination are associated
with the largest number of malignancies, including many sporadic TNBCs. These deficiencies
render cells more dependent on PARP for DNA repair and, hence, are more prone to cytotoxicity
induced by PARP inhibition. In particular, tumor cells with BRCA1 or BRCA2 deficiencies are
exquisitely sensitive to PARP inhibition, even in the absence of any other insults.
Identification of sporadic TNBC with defects in homologous recombination and mismatch repair
independent of germline mutation of BRCA 1 and 2 is an active area of research interest.

PARP-enabled DNA repair may also compensate for the loss of other repair pathways. Higher
expression of PARP in cancer cells compared to normal cells has been linked to drug
resistance and the overall ability of cancer cells to sustain genotoxic stress.

The combination of platinum based chemotherapy and PARP inhibition may be most effective in
TNBC, and particularly in subsets of TNBC. This combination may also be active in tumors with
a germline BRCA1-deficiency and/or basal phenotype, since a defect in the DNA double-strand
break repair pathway should increase sensitivity to these agents. The addition of a PARP
inhibitor to platinum based chemotherapy may induce a "double hit" to tumor cells lacking
homologous recombination without causing excess toxicity to normal cells. ABT-888 may be used
in combination with the DNA damaging agent, cisplatin, to potentiate its cytotoxic effect and
with vinorelbine to enhance tumor response rate. Safety and preliminary efficacy of veliparib
in combination with cisplatin and vinorelbine in patients with advanced triple negative and
BRCA-associated breast cancer has been reported.

1. Inclusion Criteria Roll-over patients: This protocol allows for the inclusion of 3
patients actively participating in protocol 7161 who are expected to continue to
benefit from uninterrupted dosing of veliparib monotherapy.

For newly enrolled patients the following criteria should be satisfied within 28 days
of Day 1 of protocol treatment. Results from routine clinical evaluations within 28
days prior to enrollment may be used to determine eligibility:

- Locally recurrent and not amenable to surgical therapy, and/or metastatic breast
cancer

- Confirmed HER2-, BRCA1 or BRCA2 mutation-associated breast cancer or sporadic
triple negative breast cancer.

- No opportunity to receive veliparib under a current clinical trial.

- Patients may have had any number of prior lines of chemotherapy, endocrine
therapy, immunologic, or biologic regimens for metastatic breast cancer.

- Patients receiving bisphosphonates, denosumab or LHRH-agonists are eligible.

- 18 years and older.

- Performance status > 60% on the Karnofsky scale (ECOG < 2).

- Adequate hematologic, renal and hepatic function as follows:

- Bone Marrow: Absolute neutrophil count (ANC) > 1,500/mm3 (1.5 × 109/L); Platelets
> 100,000/mm3 (100 × 109/L); Hemoglobin > 9.0 g/dL

- Serum creatinine < 1.5 × upper normal limit of institution's normal range OR
creatinine clearance > 50 mL/min/1.73m2 for patients with creatinine levels above
institutional normal;

- Hepatic function: AST and/or ALT < 2.5 × the upper normal limit of institution's
normal range.

o For patients with liver metastases, AST and/or ALT < 5 × the upper normal limit
of institution's normal range;

- Bilirubin < 1.5 × the upper normal limit of institution's normal range;

o Patients with Gilbert's Syndrome may have a bilirubin > 1.5 × the upper normal
limit of institution's normal range.

- Women of childbearing potential must agree to use adequate contraception (one of
the following listed below) prior to protocol entry, for the duration of protocol
participation and for 90 days following completion of therapy. Women of
childbearing potential must have a negative serum pregnancy test within 21 days
prior to initiation of treatment and/or be confirmed as having postmenopausal
status. Criteria for determining menopause include any of the following: prior
bilateral oopherectomy; age > 60 years; age < 60 years and amenorrheic for at
least 12 months in the absence of chemotherapy, endocrine therapy, or ovarian
suppression and FSH and estradiol in the postmenopausal range.

- Total abstinence from sexual intercourse (minimum one complete menstrual cycle);

- Vasectomized partner of female patients;

- Hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months
prior to study drug administration;

- Double-barrier method (condoms, contraceptive sponge, diaphragm or vaginal ring
with spermicidal jellies or cream);

- IUD (Intra-Uterine Device).

- Additionally, male patients (including those who are vasectomized) whose partners
are pregnant or might be pregnant must agree to use condoms for the duration of
the treatment plan and for 90 days following completions of therapy.

- Radiation therapy must have been completed at least 2 weeks prior to the
enrollment date.

- Patients with known brain metastases must have clinically controlled neurologic
symptoms, defined as surgical excision and/or radiation therapy followed by 14
days of stable neurologic function prior to the first dose of study drug.

- Ability to understand and the willingness to sign a written informed consent
document.

2. Exclusion Criteria

- Prior treatment with PARP inhibitor (excluding iniparib). Patients participating
in protocol 7161 (NCI-2010-00356) are eligible.

- Clinically significant and uncontrolled major medical condition(s) including but
not limited to:

- Active uncontrolled infection;

- Symptomatic congestive heart failure;

- Unstable angina pectoris or cardiac arrhythmia;

- Psychiatric illness/social situation that would limit compliance with protocol
requirements;

- Any medical condition, which in the opinion of the investigator, places the
patient at an unacceptably high risk for toxicities;

- Myelodysplastic syndrome;

- History of seizures within last 12 months or known neurological disorder
pre-disposing to seizures

- Patient is pregnant or lactating.