Hepatitis C Virus(HCV) Heart and Lung Study

This is a multicenter study in HCV infected adult patients who also have either advanced
cardiac disease, or advanced lung disease. Advanced cardiac disease is defined as a marked
limitation of physical activity, or discomfort upon physical activity. The patients in the
advanced cardiac disease group must also have been hospitalized for heart failure within the
last 12 months.

Advanced lung disease is defined as patients who have been diagnosed with chronic obstructive
pulmonary disease (COPD) or interstitial lung disease (ILD). Patients in the COPD group must
have abnormalities in their forced expiratory volume (FEV) test, which measures the amount of
air exhaled. They may or may not need supplemental oxygen. Patients in the ILD group must
have been diagnosed with ILD and require supplement oxygen at all times.

Inclusion Criteria:

- Chronic HCV Infection of Genotype 1, 4, 5, or 6

- HCV RNA > 103 IU/mL at screening

- 18 years of age or older

- Diagnosis of chronic HCV infection, defined as positive HCV antibody or HCV RNA more
than 6 months prior to screening OR an assessment of fibrosis F2 or greater prior to
screening.

Subjects in the advanced heart failure cohort must meet all HCV criteria, and all of the
following criteria:

- New York Heart Association (NYHA) Class III or IV functional classification

- NYHA Class III: Subjects with cardiac disease resulting in marked limitation of
physical activity. They are comfortable at rest. Less than ordinary physical
activity causes fatigue, palpitation, dyspnea, or anginal pain.

- NYHA Class IV: Patient with cardiac disease resulting in inability to carry on
any physical activity without discomfort. Symptoms of cardiac insufficiency or of
the anginal syndrome may be present even at rest. If any physical activity is
undertaken, discomfort is increased.

- ejection fraction ≤ 30%

- hospitalized for heart failure in last 12 months

Subjects in the advanced lung disease cohort must have been diagnosed with chronic
obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) must meet all HCV
criteria, and meet the following criteria for COPD or ILD:

- ILD criteria: diagnosis of interstitial lung disease with chronic supplemental oxygen
requirement at rest and/or with exertion.

- COPD criteria (one of the following):

- Forced expiratory volume (FEV1)< 30% predicted

- OR any FEV1 with chronic supplemental oxygen requirement at rest and/or with
exertion

- OR any FEV1 with chronic hypercapnia (baseline partial pressure of arterial
carbon dioxide [PaCO2] > 45)

Exclusion Criteria:

- Chronic HCV Infection with Genotype 2 or 3

- Treatment with any of the following agents

- Amiodarone. Subjects previously treated with amiodarone must have stopped the
amiodarone at least 60 days prior to day 1 of SOF/LDV FDC

- Carbamazepine, phenytoin, phenobarbital, oxcarbazepine

- Rifabutin, rifampin or rifapentine

- HIV regimens containing tenofovir or tipranavir/ritonavir

- St. John's wort

- Rosuvastatin

- Have any serious or active medical or psychiatric illness which, in the opinion of the
investigator, would interfere with subject treatment, assessment, or compliance

- History of hepatic encephalopathy or variceal hemorrhage

- Hepatitis B surface antigen positive

- Abnormal hematological and biochemical parameters, including:

- Hemoglobin (Hb) < 8 g/dL

- Platelets ≤ 50,000/mm3

- alanine aminotransferase (ALT), aspartase aminotransferase (AST), or alkaline
phosphatase ≥ 10 times upper limit of normal(ULN)

- Total bilirubin > 3 mg/dl

- Severe renal impairment creatinine clearance (CrCl), i.e. < 30 mL/min.

- History of major organ transplantation with an existing functional graft.

- History of clinically-significant drug allergy to nucleoside/nucleotide analogs.

- Pregnant women or women planning to become pregnant

- Women who are breastfeeding

- Active or recent history (≤ 1 year) of drug or alcohol abuse