A Study of Investigational Dulaglutide Doses in Participants With Type 2 Diabetes on Metformin Monotherapy

Inclusion Criteria:

- Have had type 2 diabetes (T2D) for ≥6 months according to the World Health
Organization (WHO) classification

- Have HbA1c of 7.0% to 10.0%, inclusive, as assessed by the central laboratory

- Have been treated with stable doses of metformin for at least 3 months

- Have a body mass index (BMI) ≥25 kilograms per square meter

Exclusion Criteria:

- Have type 1 diabetes (T1D)

- Have used any glucose-lowering medication other than metformin 3 months prior to study
entry or during screening/lead-in period or have used any glucagon-like peptide-1
receptor agonists (GLP-1 RAs) at any time in the past

- Have had any of the following cardiovascular conditions: acute myocardial infarction
(MI), New York Heart Association Class III or Class IV heart failure, or
cerebrovascular accident (stroke)

- Have acute or chronic hepatitis, signs and symptoms of any other liver disease other
than nonalcoholic fatty liver disease (NAFLD), or alanine aminotransferase (ALT) level
>2.5 times the upper limit of the reference range, as determined by the central
laboratory at study entry; participants with NAFLD are eligible for participation in
this trial

- Have had chronic or acute pancreatitis any time prior to study entry

- Have an estimated glomerular filtration rate (eGFR) <45 milliliters/minute/1.73 square
meter, calculated by the Chronic Kidney Disease-Epidemiology (CKD-EPI) equation

- Have serum calcitonin ≥20 picograms per milliliter, as determined by the central
laboratory at study entry