Brief CBT for the Treatment of Depression During Inpatient Hospitalization

Participants assigned to the CBT condition will receive the usual standard of care during an
inpatient psychiatric hospitalization. This includes but is not limited to medication
management, group therapy, and individual therapy. If a patient is randomly assigned to the
enhanced CBT group, manualized CBT, including a sequence of sessions that builds upon prior
sessions and planned exercises, including worksheets and journal entries.The training M.D.,
who is a treating physician on HCC-10, will also intermittently and randomly observe the CBT
sessions to ensure the manual properly is being followed. Although the control condition may
contain elements of CBT as per the clinician completing the therapy, it is not manualized,
does not include specific exercises to be completed between sessions, and is not a course
that builds upon skills from the previous day, as in the CBT condition. Participants assigned
to the control condition will receive the usual standard of care during an inpatient
psychiatric hospitalization. This includes but is not limited to medication management, group
therapy, and individual therapy.

Inclusion Criteria:

- Diagnosed with depression according to Diagnostic and Statistical Manual of Mental
Disorders, Fifth Edition (DSM-V) criteria on initial assessment on the unit.

- Demonstrates at least moderate degree of depressive symptoms on MADRS, HAM-D, and
CGI-S.

- Provides written informed consent.

Exclusion Criteria:

- A mental illness other than depression that is the primary cause of treatment, as
determined by the Principal Investigator.

- A cognitive or neurologic disorder that inhibits ability to engage in CBT.