Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer

Status:	Recruiting
Conditions:	Cancer, Cancer
Therapuetic Areas:	Oncology
Healthy:	No
Age Range:	18 - Any
Updated:	3/27/2019
Start Date:	October 3, 2016
End Date:	October 2021
Contact:	Nancy Lee, MD
Phone:	212-639-3341

A Phase II Randomized Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Unilateral Head and Neck Cancer

Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy
tissues. It is possible that side effect rates with PBRT will be lower or the same compared
to IMRT, but this has not been well studied to date. Although both of these radiation
therapies have been used in the past to treat head and neck cancer, this research study will
compare the effects of these two different radiation treatment modalities with each other to
see whether PBRT is better, the same or worse than IMRT.

Inclusion Criteria:

- Age greater than or equal to 18.

- Histopathologically confirmed diagnosis of one the following cancer types:

- Salivary gland cancer without the presence of extracapsular extension and/or
positive surgical margin.

- Skin cancer

- Melanoma

- Patients must be a candidate for ipsilateral radiation therapy.

- Karnofsky performance status ≥70.

- Negative pregnancy test for women of childbearing potential (<51 years of age) as per
institutional policy.

Exclusion Criteria:

- Any prior head or neck irradiation.

- Physician recommendation of bilateral neck radiation.

- Non-resectable disease

- Physician recommendation of mucosal radiation

- Use of chemotherapy

We found this trial at

sites

Memorial Sloan Kettering Monmouth

Middletown, New Jersey 07748

Phone: 212-639-3341

from

Middletown, NJ