A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Men and women ages ≥ 18 years old

- Documented or suspected infection

- Severe sepsis or septic shock for at least 24 hours

- Sepsis-induced immunosuppression

- In Intensive Care Unit (ICU) with no plans to discharge in next 24 hours

Exclusion Criteria:

- Previous episode of severe sepsis or septic shock with ICU admission during the
current hospitalization

- Autoimmune disease

- Organ or bone marrow transplant

- Cancer treatment in the past 6 weeks

- Human immunodeficiency virus (HIV) infection and not on therapy prior to this episode
of sepsis; hepatitis C virus(HCV) infection and still has virus (not cured); Chronic
hepatitis B virus (HBV) infection and not on treatment

Other protocol defined inclusion/exclusion criteria could apply