Comparing the Effects of Smoked and Oral Marijuana in Individuals With HIV/AIDS



Status:Completed
Conditions:HIV / AIDS, Psychiatric
Therapuetic Areas:Immunology / Infectious Diseases, Psychiatry / Psychology
Healthy:No
Age Range:21 - 50
Updated:1/12/2017
Start Date:December 2001
End Date:August 2005

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Trial Summary
Trial Overview
Inclusion Criteria

THC and Marijuana--Effects in Individuals With HIV/AIDS

Smoked marijuana (MJ) and dronabinol (also known as THC or by the trade name Marinol) are
used to increase appetite, food intake, and weight in patients with HIV who experience
unintended weight loss. This study will compare the effects of MJ and Marinol use in
marijuana smokers who are HIV infected.

Little is known about the efficacy and tolerability of oral THC versus smoked MJ in a
clinically relevant population. Additionally, it is not clear how THC's effects vary as a
function of the duration of treatment or the patient's current patterns of smoked MJ use.
This study directly compares 3 doses of smoked marijuana and 3 doses of Marinol across a
range of behavioral measures in HIV infected marijuana smokers.

Outcome measures will include analysis of food intake, body composition, mood, physical
symptoms (e.g., nausea, stomach pain), psychomotor task performance, and sleep.

Inclusion Criteria

- HIV infected

- Smoke marijuana

- Taking HIV medications

Exclusion criteria

- Naive marijuana smokers

- People with history of respiratory/pulmonary disease
We found this trial at
1
site
New York State Psychiatric Institute
1051 Riverside Dr
New York, New York 10032
646-774-5000
New York State Psychiatric Institute The New York State Psychiatric Institute (NYSPI), established in 1895,...
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mi
from
New York, NY
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