The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

This study plans to learn more about the effect of pilocarpine on intraocular pressure and
ocular perfusion pressure for a full twenty-four hour period.

In this study, the investigators seek to better characterize the knowledge base of the
intraocular pressure (IOP) lowering effects of pilocarpine in patients with open angle
glaucoma or ocular hypertension who are currently taking latanoprost. The goal is to define
the potential additive effect of pilocarpine throughout a 24-hour period, not only for IOP,
but for ocular perfusion pressure (defined as 2/3[diastolicBP + 1/3(systolicBP -
diastolicBP)] - IOP). These data will allow to expand current knowledge of the effects of
pilocarpine and help determine if this medication has a useful role as an adjunctive
treatment in glaucoma.

Inclusion Criteria:

- Current confirmed diagnosis of:

- open angle glaucoma, or

- ocular hypertension including pigment dispersion glaucoma, and

- pseudoexfoliation glaucoma.

- Current use of topical latanoprost once a day in both eyes for at least 6 weeks

- any race/ethnicity

Exclusion Criteria:

- Females who are currently pregnant or planning to become pregnant during the study
period

- Diagnosis of any other form of glaucoma other than open-angle

- Intraocular pressure readings of <14mmHg in either eye when measured during routine
office visit in the past 12 months.

- Schaffer angle grade < 2 in either eye by gonioscopy

- Intraocular surgery within 6 months or laser within 3 months

- History of retinal tear or detachment in either eye

- Active iritis in either eye as determined by most recent eye examination

- Patients who smoke or have irregular daily sleep patterns

- Patients who have started or changed glucocorticoids therapy in the last 3 months

- Patients who are currently using medical or recreational marijuana

- Any use of a non-FDA approved medication for glaucoma in the last 3 months