Tranexamic Acid and Blood Clots in Knee Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/21/2018 |
| Start Date: | January 2017 |
| End Date: | December 2018 |
| Contact: | Tim Petersen, PhD |
| Email: | timpetersen@salud.unm.edu |
| Phone: | 5052721762 |
Does the Intraoperative Administration of Tranexamic Acid (TXA) Increase the Incidence of Deep Venous Thrombosis in Total Knee Arthroplasty?
This is an observational trial to estimate the incidence of deep vein thrombosis (DVT) in
total knee replacement patients who received an intraoperative dose of tranexamic acid.
total knee replacement patients who received an intraoperative dose of tranexamic acid.
This study is anticipated to consist of 30 participants over 18 years of age scheduled for
total knee arthroplasty at Sandoval Regional Medical Center with administered intraoperative
tranexamic acid, who do not meet the exclusion criteria. The patients will be examined on
postoperative day 1. Lower-extremity ultrasound will be used to screen for deep vein
thrombosis (DVT). Incidence data for DVT will then be compared with the historical incidence
rate at our institution for total knee arthroplasty without the use of tranexamic acid, which
is approximately 12%. Patients found on screening to have deep vein thrombosis will be
referred for appropriate care.
total knee arthroplasty at Sandoval Regional Medical Center with administered intraoperative
tranexamic acid, who do not meet the exclusion criteria. The patients will be examined on
postoperative day 1. Lower-extremity ultrasound will be used to screen for deep vein
thrombosis (DVT). Incidence data for DVT will then be compared with the historical incidence
rate at our institution for total knee arthroplasty without the use of tranexamic acid, which
is approximately 12%. Patients found on screening to have deep vein thrombosis will be
referred for appropriate care.
Inclusion Criteria:
- Adult patients scheduled for total knee arthroplasty at Sandoval Regional Medical
Center with an intraoperative dose of tranexamic acid
Exclusion Criteria:
- Previous deep vein thrombosis or pulmonary embolism episode
- Known coronary artery disease or peripheral vascular disease
- Previously diagnosed hypercoagulable states (e.g. Leiden factor V, antiphospholipid
antibody, protein C or S deficiency)
- Pregnancy
- Creatinine clearance less than 30 ml/min
- Non-fluency in English
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