Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
| Status: | Terminated |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 1/13/2017 |
| Start Date: | September 2002 |
| End Date: | January 2004 |
Transitioning Patients From Methadone to Buprenorphine/Naloxone for Treating Opioid Dependence
Buprenorphine is a drug that may be helpful in treating opioid dependent individuals who
were previously maintained on methadone. The purpose of this study is to determine the
effects of different doses of buprenorphine/naloxone in treating opioid dependent
individuals who were previously maintained on methadone.
were previously maintained on methadone. The purpose of this study is to determine the
effects of different doses of buprenorphine/naloxone in treating opioid dependent
individuals who were previously maintained on methadone.
Buprenorphine is a mixed agonist-antagonist opioid that is being developed as a treatment
for opioid dependence. Because buprenorphine is a partial mu agonist opioid, under certain
conditions it is possible for buprenorphine to precipitate opioid withdrawal in opioid
dependent individuals. A person with a high level of physical dependence could experience
buprenorphine-related precipitated withdrawal. The purpose of this study is to test the
acute effects of different doses of buprenorphine/naloxone in opioid dependent individuals
maintained on methadone. The study is designed to provide dosing schedules similar to those
that might be initially used in a physician's office.
for opioid dependence. Because buprenorphine is a partial mu agonist opioid, under certain
conditions it is possible for buprenorphine to precipitate opioid withdrawal in opioid
dependent individuals. A person with a high level of physical dependence could experience
buprenorphine-related precipitated withdrawal. The purpose of this study is to test the
acute effects of different doses of buprenorphine/naloxone in opioid dependent individuals
maintained on methadone. The study is designed to provide dosing schedules similar to those
that might be initially used in a physician's office.
Inclusion Criteria:
- Meets criteria for opioid dependence
Exclusion Criteria:
- Significant medical or psychiatric illness
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