Infusion Laboratory: Protocol 1 - Selegeline - 2

To develop a medication for the treatment of cocaine addiction using a medical human
physio-neuro-psycho-immunology laboratory setting. To characterize this cocaine abusing
population on a variety of psychological and physicologically measures over time from
withdrawal through pere and post cocaine administration. To determine the effects of
selegeline on the subjective and physiological effects of cocaine challenge in chronic crack
abusers. To evaluate clinical safety issues pertaining to selegeline, to cocaine and their
interaction in a chronic crack dependent population.

Inclusion Criteria:

M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the
study and sign informed consent.

Exclusion Criteria:

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical condtions that deem participation to be unsafe.