Naltrexone in Treatment of Cocaine Dependence - 5
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/13/2017 |
| Start Date: | May 1995 |
| End Date: | July 1996 |
Naltrexone in Treatment of Cocaine Dependence
The purpose of this study is to determine the efficacy of naltrexone in the treatment of
cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2)
decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in
treatment.
cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2)
decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in
treatment.
Double-blind, placebo controlled study of the safety and efficacy of naltrexone in treating
cocaine dependence in a patient sample that initiated the study while in an inpatient
setting and were then followed-up for 3 months as outpatients.
cocaine dependence in a patient sample that initiated the study while in an inpatient
setting and were then followed-up for 3 months as outpatients.
Inclusion Criteria:
1. Meet DSM-III-R criteria for cocaine dependency,
2. 18 to 65 years of age,
3. capable of understanding the study,
4. voluntarily signed consent,
5. male or non-pregnant female using approved form of birth control.
Exclusion Criteria:
1. abnormal liver function tests (SGOT, SGPT, or GGT greater than twice the normal
values),
2. opioid use within the last 7 days,
3. use of neuroleptics,
4. having a severe acute medical problem,
5. unable to complete psychiatric rating scales, or
6. judged by the investigator to be unlikely to comply with the study protocol
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