Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1

Patients randomized to the BUP/NX arm will receive daily doses for 13 days with sublingual
administration of 2 mg buprenorphine/0.5 mg naloxone tablet(s) and/or an 8 mg
buprenorphine/2.0 mg naloxone tablet(s). The starting dose on day 1 is 4 mg/1 mg BUP/NX with
an additional 4 mg/1 mg, if needed, escalating in a step-wise manner to 16 mg/4 mg BUP/NX on
day 3 and tapering to 2 mg/ 0.5 mg BUP/NX by days 12 to 13. Patients randomized to the
clonidine arm will receive oral clonidine (0.05 to 0.1 mg depending upon weight) every 4 to
6 hours for 24 hours not to exceed 0.6 mg total on day 1. On day 2, a clonidine transdermal
patch will be applied (0.1 mg/day/7-day patch with number of patches adjusted by weight).
Oral clonidine will continue to be given on the second day of detoxification and increased
to 0.2 mg every 6 hours or 0.1 mg every 3 hours not to exceed 0.8 mg over 24 hours. Patches
will be worn all 13 days of detoxification. The dose of clonidine will be adjusted according
to the proposed detoxification schedule, patient's weight, tolerance, and systolic blood
pressure. Patients will receive counseling according to procedures in existence at each CTP
throughout the study. Self-help detoxification handbooks will be distributed to all study
participants.

Inclusion Criteria:

1. Treatment-seeking males and non-pregnant and non-lactating females, 15 years and
older, who fulfill DSM-IV criteria for opiate dependence, report experiencing
symptoms of opiate withdrawal, are currently physically dependent on opioids and are
in need of medical assistance for opioid withdrawal.

2. Systolic blood pressure 100 mm Hg, and pulse 56 bpm.

3. Good general health or, in case of a medical/psychiatric condition needing ongoing
treatment, under the care of a physician willing to continue patient's medical
management and cooperate with the study physicians.

4. Agreeable to and capable of signing the informed consent approved by an institutional
review board and, if under the age of 18 (excluding emancipated minors), assent and
concurrent consent from a parent or legal guardian.

5. Use of one of the following acceptable methods of birth control by female patients of
childbearing potential:

1. oral contraceptives

2. barrier (diaphragm or cervical cap) with spermicide or condom

3. intrauterine progesterone contraceptive system

4. levonorgestrel implant

5. medroxyprogesterone acetate contraceptive injection

6. complete abstinence from sexual intercourse

Exclusion Criteria:

1. Medical condition that would make participation, in the opinion of the study
physician, medically hazardous (e.g., acute hepatitis, unstable cardiovascular, liver
or renal disease);

2. Clinically significant abnormalities in ECG.

3. Known allergy or sensitivity to buprenorphine, naloxone, or clonidine.

4. Receiving beta-blockers, calcium channel blockers, tricyclics, digitalis and other
medications which may interact adversely with clonidine.

5. Acute severe psychiatric condition in need of immediate treatment, or imminent
suicide risk.

6. Dependence on alcohol, benzodiazepines or other depressants, or stimulants, and
requiring immediate medical attention.

7. Participation in an investigational drug study, including buprenorphine, within the
past 30 days.

8. Methadone or LAAM maintenance or detoxification within 30 days of enrollment.

9. Pending legal action that could prohibit or interfere with participation.

10. Unable to remain in area for duration of active phase of treatment.

11. Females that are pregnant, lactating, or planning to become pregnant.