Seasonal Affective Depression (SAD) Study

A 7-Month Multicenter, Parallel, Double-Blind, Placebo-Controlled Comparison of
150-300mg/day of Extended-release Bupropion Hydrochloride and Placebo for the Prevention of
Seasonal Depressive Episodes in Subjects with a History of Seasonal Affective Disorder
Followed by an 8-week Observational Follow-up Phase

Inclusion Criteria:

- History of Major Depressive Disorder (MDD) with a seasonal pattern.

Exclusion Criteria:

- Current or past history of seizure disorder or brain injury.

- History or current diagnosis of anorexia nervosa or bulimia.

- Recurrent summer depression more frequently than winter depression.

- Primary diagnosis of panic disorder, Obsessive Compulsive Disorder (OCD),
Post-traumatic Stress Disorder(PTSD), acute distress disorder, bipolar II disorder or
other psychotic disorders.

- Initiated psychotherapy within the last 3 months.