Testing New Method of Analyzing MR Images

The purpose of this study is to develop and evaluate new MR imaging techniques and protocols
for non-invasive monitoring of anti-angiogenesis treatment of breast cancer. This
feasibility study is a preliminary imaging study to test this imaging protocol on subjects
already undergoing MR for clinical purposes.

The specific objective of this research study is to develop and validate both MRI and
functional MRI data acquisition methods, task paradigms, and post-processing techniques to
ensure reliability of results.

The information derived from this research is intended to be applied to a future study of
subjects undergoing experimental anti-angiogenesis drug therapy.

Inclusion Criteria:

- Females

- Age 18 years or greater

- Undergoing breast MRI exam

Exclusion Criteria:

- Pregnancy

- Contraindication for MRI on standard screening checklist for clinically indicated
examinations (i.e. metal devices/implants; history of claustrophobia)

- History/presence of any of the following to the breast: injury; breast implant;
surgical or interventional procedure; clinically significant abnormality