Benchmarking an Oral Anticoagulant Treatment Rate in Patients With Nonvalvular Atrial Fibrillation

At participating centers within the American College of Cardiology's (ACC) PINNACLE Registry,
patients with nonvalvular atrial fibrillation who, according to ACC guidelines, are indicated
as having an indication for oral anticoagulants (OA), but who are not receiving them, will be
identified. Recruitment of participating physicians will also take place through
collaboration with the PINNACLE Registry. Physician and patient participants will be asked to
complete clinical surveys characterizing use and perception of OA therapy for each individual
patient. The Baim Institute for Clinical Research (Baim Institute) serves as an analytic
center for the PINNACLE Registry and will collaboratively lead this project with the ACC. The
information collected from the PINNACLE Registry will include patient characteristics, site
characteristics (volume, region, etc.) and the treating physician characteristics.
Information from the patient and physician surveys will provide the clinical reasons for
prior nontreatment as assessed by the treating physicians as well as the patients' perception
of OA treatment (overall and according to pre-specified subgroups based on patient and site
characteristics). Information will also be gathered from the patients' chart.

The above data will be compiled and reviewed by a committee of cardiologists who will assess
whether OA treatment would be appropriate based on all the clinical factors assessed.

The BOAT-AF data will be linked to data from the PINNACLE Registry for the patients for whom
surveys have been collected. Linking the two datasets will allow assessment of whether or not
the participating physicians prescribed OA treatment and whether those patients started OA
treatment within approximately 12 months after completing the questionnaire.

Inclusion Criteria: A patient must meet all of the following criteria to participate in
this study:

- Able and willing to complete the survey;

- Diagnosed with nonvalvular atrial fibrillation and CHA2DS2-VASc ≥ 2;

- Not currently treated with oral anticoagulants according to the PINNACLE Registry
data;

- Enrolled in the PINNACLE Registry;

- Last physician office visit within the prior 18 months; and

- Age ≥ 18 years.

Exclusion Criteria: A patient will be excluded from participating in the study for any of
the following reasons:

- Patient is no longer being followed at the local practice;

- Patient declines participation; and/or

- Patient is unable to speak or read English.