Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study)

Inclusion Criteria:

- Diagnosed with primary open-angle glaucoma (POAG) in the study eye.

- Pseudophakic with Posterior Chamber IOL (PCIOL)

- Able and willing to attend follow up visits for two years post-operative

- Able and willing to sign informed consent

Exclusion Criteria:

- Phakia or aphakia

- Previous glaucoma procedure with or without an implantable glaucoma device (including
incisional surgery, ALT, iridectomy/iridotomy, etc.) [Subjects with one prior SLT
application (>3 months prior to screening) or prior ECP (performed > 12 months prior
to screening) can be enrolled].

- Use of more than 3 ocular hypotensive medications (combination medications count as 2
medications)

- Diagnosis of acute angle closure, traumatic, congenital, malignant, uveitic,
pseudoexfoliative, pigmentary or neovascular glaucoma

- Abnormal angle anatomy as determined by gonioscopy (e.g. peripheral anterior
synechiae, rubeosis or other angle abnormalities)

- Participation in any clinical trial ≤ 30 days prior to screening