Effect of Growth Hormone in Children With Growth Hormone Deficiency

Inclusion Criteria:

- Clinically suspected GHD

- Height < -2.0 SDS

- Serum IGF-I less than or equal to -1.0 SDS

- Bone age less than or equal to 9 years for boys and less than or equal to 7 years for
girls.

- Puberty Tanner Stage I

Exclusion Criteria:

- Previous use of growth hormone

- Growth retardation attributable to causes other than GHD (e.g. inborn errors of
metabolism, primary bone disease, chromosomal disorders, etc.)

- Intrauterine growth retardation: birth weight < 3rd percentile.

- Administration of other growth-altering medications.

- Evidence of any malignancy or intracranial tumors.