Dose Finding and Safety Study of Deferoxamine in Patients With Brain Hemorrhage
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/17/2018 |
| Start Date: | July 2008 |
| End Date: | April 2010 |
Safety and Tolerability of Deferoxamine in Acute Cerebral Hemorrhage
Animal studies show that the breakdown of blood results in iron accumulation in the brain
after brain hemorrhage (ICH); and that iron plays a role in brain injury in ICH patients.
Deferoxamine (DFO) has been extensively used in clinical practice for more than 30 years to
remove excessive iron from the body, and has been shown to provide some benefit in animal
studies of ICH. Therefore, we plan to undertake this study to evaluate the safety and
tolerability of treatment with DFO in patients with ICH, and to determine the maximal
tolerated dose to be used in future studies to determine if treatment with DFO can improve
the outcome of patients with ICH.
Our main objectives are: 1) to evaluate the safety and tolerability of varying doses of DFO,
by determining the treatment related adverse events, in patients with ICH; and 2) to
determine the maximal tolerated dose to be adopted in subsequent studies to test the efficacy
of DFO in improving outcome after ICH.
We hypothesize that DFO is well-tolerated and has minimal serious adverse effects in patients
with ICH; and that treatment with DFO will improve patients' outcome. The results can
potentially bring into account new means to improve the outcome of patients with ICH. ICH is
a frequent cause of disability and death. A successful study demonstrating the efficacy of
iron-modifying therapy would be of considerable public health significance.
after brain hemorrhage (ICH); and that iron plays a role in brain injury in ICH patients.
Deferoxamine (DFO) has been extensively used in clinical practice for more than 30 years to
remove excessive iron from the body, and has been shown to provide some benefit in animal
studies of ICH. Therefore, we plan to undertake this study to evaluate the safety and
tolerability of treatment with DFO in patients with ICH, and to determine the maximal
tolerated dose to be used in future studies to determine if treatment with DFO can improve
the outcome of patients with ICH.
Our main objectives are: 1) to evaluate the safety and tolerability of varying doses of DFO,
by determining the treatment related adverse events, in patients with ICH; and 2) to
determine the maximal tolerated dose to be adopted in subsequent studies to test the efficacy
of DFO in improving outcome after ICH.
We hypothesize that DFO is well-tolerated and has minimal serious adverse effects in patients
with ICH; and that treatment with DFO will improve patients' outcome. The results can
potentially bring into account new means to improve the outcome of patients with ICH. ICH is
a frequent cause of disability and death. A successful study demonstrating the efficacy of
iron-modifying therapy would be of considerable public health significance.
An open-label, safety, tolerability, and dose-finding study using the continuous reassessment
method.
method.
Inclusion Criteria:
1. Age ≥ 18 years
2. The diagnosis of ICH is confirmed by brain CT scan.
3. The first dose of the study drug can be administered within 18 hours of ICH symptom
onset.
4. Signed and dated informed consent is obtained
5. Stable clinical and neurological status. Patients whose clinical or neurological
status significantly deteriorates compared to presentation prior to administration of
the study drug will be excluded.
Exclusion Criteria:
1. Previous chelation therapy or known hypersensitivity to DFO products
2. Abnormal renal function (serum creatinine > 2 mg/dl)
3. Known severe iron deficiency anemia
4. Planned surgical evacuation of ICH prior to administration of the study drug
5. Patients with suspected secondary ICH related to tumour, coagulopathy, ruptured
aneurysm or arteriovenous malformation, or venous sinus thrombosis
6. Evidence of significant shift of midline brain structure (> 10 mm) or herniation on
imaging studies.
7. Deep coma (Glasgow Coma Score (GCS) = 3-5) upon presentation
8. Taking iron supplements or prochlorperazine
9. Patients with heart failure taking > 500 mg of vitamin C daily
10. Known hearing impairment
11. Systolic blood pressure < 100 mmHg or diastolic blood pressure < 60 mmHg, confirmed by
3 consecutive readings
12. Significant chronic respiratory insufficiency
13. Known pregnancy (or positive pregnancy test), or breast-feeding
14. Patients known or suspected of not being able to comply with the study protocol due to
alcoholism, drug dependency, incompliance, or any other cause.
15. Any condition which, in the judgement of the investigator, might increase the risk to
the patient
16. Life expectancy of less than 90 days due to co-morbid conditions
17. Concurrent participation in another research protocol for investigation of another
experimental therapy
18. Pre-existing Do Not Resuscitate (DNR) order, or indication that a new DNR order will
be implemented within the first 48 hours of hospitalization. -
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