A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/2/2019
Start Date:January 13, 2017
End Date:November 8, 2028
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Randomized, OpenLabel, Phase 3 Trial of Nivolumab Plus Ipilimumab or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Early Stage NSCLC

The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and
chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus
ipilimumab's safety and effectiveness in treating resectable NSCLC.

This study has multiple primary endpoints.

The first primary completion date of Pathological Complete Response is anticipated to be
reached April 2020.

The completion date for all primary outcome measures is expected May 2023.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Early stage IB-IIIA, operable non-small cell lung cancer, confirmed in tissue

- Lung function capacity capable of tolerating the proposed lung surgery

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1

- Available tissue of primary lung tumor

Exclusion Criteria:

- Presence of locally advanced, inoperable or metastatic disease

- Participants with active, known or suspected autoimmune disease

- Prior treatment with any drug that targets T cell co-stimulations pathways (such as
checkpoint inhibitors)

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
77
sites
University of Miami
Deerfield Beach, Florida 33442
Phone: 954-698-3616
?
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland 21231
410-955-6190
Phone: 410-502-8737
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Phone: 617-632-3468
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Fort Wayne Medical Oncology and Hematology
11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Phone: 260-969-7876
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-322-4967
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Orlando Health
24 Sturtevant St
Orlando, Florida 32806
Phone: 321-841-3812
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Phone: 503-418-9389
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
Indian River Med. Ctr.
1000 36th Street
Vero Beach, Florida 32960
Phone: 772-226-4960
?
mi
from
Vero Beach, FL
Click here to add this to my saved trials
Local Institution
Athens, Georgia 30607
?
mi
from
Athens, GA
Click here to add this to my saved trials
Texas Oncology, PA at South Austin Cancer Center
Austin, Texas 78745
?
mi
from
Austin, TX
Click here to add this to my saved trials
Medstar Franklin Sqaure Medical Center
Baltimore, Maryland 21237
Phone: 443-777-7364
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Texas Oncology, P.A.
Bedford, Texas 76022
Phone: 817-359-9000
?
mi
from
Bedford, TX
Click here to add this to my saved trials
St. Vincent Frontier Cancer Center
Billings, Montana 59102
Phone: 406-238-6290
?
mi
from
Billings, MT
Click here to add this to my saved trials
Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Phone: 617-632-4767
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
The University of Vermont Cancer Center
Burlington, Vermont 05405
Phone: 802-656-9916
?
mi
from
Burlington, VT
Click here to add this to my saved trials
Instituto Medico Especializado Alexander Fleming
Capital Federal, Buenos Aires
Phone: +541132218956
?
mi
from
Capital Federal,
Click here to add this to my saved trials
Charleston Hematology/Oncology Associates, Pa
Charleston, South Carolina 29403
Phone: 843-577-6957
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-4421
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Phone: 773-702-1280
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Northwestern Medicine
Chicago, Illinois 60611
Phone: 312-695-4781
?
mi
from
Chicago, IL
Click here to add this to my saved trials
The Christ Hospital
2139 Auburn Ave
Cincinnati, Ohio 45219
(513) 585-2000
Phone: 513-451-4033
The Christ Hospital For more than 120 years, The Christ Hospital has been a leader...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
MetroHealth Med Ctr
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
Phone: 216-778-3526
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Local Institution
Columbia, Missouri 65212
?
mi
from
Columbia, MO
Click here to add this to my saved trials
Rocky Mountain Cancer Center
Denver, Colorado 80218
Phone: 303-285-5081
?
mi
from
Denver, CO
Click here to add this to my saved trials
Henry Ford Health System
Detroit, Michigan 48202
Phone: 313-916-0482
?
mi
from
Detroit, MI
Click here to add this to my saved trials
WBAMC Oncology Department
El Paso, Texas 79920
Phone: 915-742-3432
?
mi
from
El Paso, TX
Click here to add this to my saved trials
Local Institution
Elizabethtown, Kentucky 42701
?
mi
from
Elizabethtown, KY
Click here to add this to my saved trials
Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-208-3173
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
?
mi
from
Fairfax, VA
Click here to add this to my saved trials
Local Institution
32 Washington Street
Fairhaven, Massachusetts 02719
?
mi
from
Fairhaven, MA
Click here to add this to my saved trials
Local Institution
Fort Gordon, Georgia 30905
?
mi
from
Fort Gordon, GA
Click here to add this to my saved trials
Local Institution
Fort Worth, Texas 76164
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Local Institution
Fredericksburg, Virginia 22408
?
mi
from
Fredericksburg, VA
Click here to add this to my saved trials
Bon Secours St. Francis Hospital
Greenville, South Carolina 29601
?
mi
from
Greenville, SC
Click here to add this to my saved trials
The Cancer Center, Hackensack University Medical Center
Hackensack, New Jersey
Phone: 551-996-8066
?
mi
from
Hackensack, NJ
Click here to add this to my saved trials
Hattiesburg Clinic
Hattiesburg, Mississippi 39401
Phone: 601-288-2495
?
mi
from
Hattiesburg, MS
Click here to add this to my saved trials
Local Institution
High Point, North Carolina 27262
?
mi
from
High Point, NC
Click here to add this to my saved trials
Memorial Regional Hospital
Hollywood, Florida 33021
?
mi
from
Hollywood, FL
Click here to add this to my saved trials
Local Institution
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Millenium Oncology
Houston, Texas 77090
Phone: 877-870-2640
?
mi
from
Houston, TX
Click here to add this to my saved trials
New York Oncology Hematology, Pc
Irving, Texas 75063
?
mi
from
Irving, TX
Click here to add this to my saved trials
Local Institution
Jacksonville, Florida 32256
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
University of Kentucky
Lexington, Kentucky
859) 257-9000
Phone: 859-218-6145
University of Kentucky The University of Kentucky is a public, land grant university dedicated to...
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Los Angeles Hematology/Oncology Medical Group
Los Angeles, California 90017
Phone: 213-977-1214
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Local Institution
Los Angeles, California 90095
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Local Institution
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Local Institution
Lubbock, Texas
?
mi
from
Lubbock, TX
Click here to add this to my saved trials
Northwest Georgia Oncology Center
Marietta, Georgia 30060
Phone: 770-333-2161
?
mi
from
Marietta, GA
Click here to add this to my saved trials
Intermountain Medical Center
5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Phone: 801-507-3950
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
?
mi
from
Murray, UT
Click here to add this to my saved trials
Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
University Medical Center New Orleans
New Orleans, Louisiana 70112
Phone: 504-702-5171
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
Local Institution
New York, New York 10016
?
mi
from
New York, NY
Click here to add this to my saved trials
Laura And Isaac Perlmutter Cancer Center
New York, New York 10016
Phone: 212-263-8696
?
mi
from
New York, NY
Click here to add this to my saved trials
Illinois Cancer Specialists
Niles, Illinois 60714
Phone: 847-827-9060
?
mi
from
Niles, IL
Click here to add this to my saved trials
Cancer Institute Of Florida
Orlando, Florida 32804
Phone: 407-303-2523
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Local Institution
Philadelphia, Pennsylvania 19102
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Phone: 215-214-3789
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Arizona Oncology Assoc, Pc-Hal
Phoenix, Arizona 85016
Phone: 602-277-4868
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Local Institution
Phoenix, Arizona 85016
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Local Institution
Pittsburgh, Pennsylvania 15240
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Allegheny General Hospital
320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Phone: 412-578-1364
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Cancer Center of Central Connecticut
Plainville, Connecticut
Phone: 860-224-4408
?
mi
from
Plainville, CT
Click here to add this to my saved trials
Local Institution
Portland, Oregon 97201
?
mi
from
Portland, OR
Click here to add this to my saved trials
Local Institution
Sacramento, California 95819
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Local Institution
1506 South Silicon Way
Saint George, Utah 84770
?
mi
from
Saint George, UT
Click here to add this to my saved trials
Southwest Regional Cancer Clinic
544 South 400 East
Saint George, Utah 84770
Phone: 435-688-4168
?
mi
from
Saint George, UT
Click here to add this to my saved trials
Huntsman Cancer Institute
Salt Lake City, Utah 84112
Phone: 801-587-4368
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Local Institution
Santa Barbara, California 93105
?
mi
from
Santa Barbara, CA
Click here to add this to my saved trials
Local Institution
Santa Rosa, California 95403
?
mi
from
Santa Rosa, CA
Click here to add this to my saved trials
Texas Cancer Center - Sherman
Sherman, Texas 75090
?
mi
from
Sherman, TX
Click here to add this to my saved trials
Local Institution
8007 183rd Street
Tinley Park, Illinois 60487
?
mi
from
Tinley Park, IL
Click here to add this to my saved trials
HOPE Cancer Center of East Texas
721 Clinic Drive
Tyler, Texas 75701
Phone: 903-595-7045
?
mi
from
Tyler, TX
Click here to add this to my saved trials
Texas Oncology
Waco, Texas 76712
?
mi
from
Waco, TX
Click here to add this to my saved trials
Valley Hospital Luckow Pavili
1 Valley Health Plaza
Westwood, New Jersey 07675
Phone: 201-634-5792
?
mi
from
Westwood, NJ
Click here to add this to my saved trials
Local Institution
Wichita, Kansas 67214
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Local Institution
Worcester, Massachusetts 01608
?
mi
from
Worcester, MA
Click here to add this to my saved trials
Genesis Health Care System
740 Adair Avenue
Zanesville, Ohio 43701
?
mi
from
Zanesville, OH
Click here to add this to my saved trials