A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/2/2019
Start Date:January 13, 2017
End Date:November 8, 2028
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Randomized, OpenLabel, Phase 3 Trial of Nivolumab Plus Ipilimumab or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Early Stage NSCLC

The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and
chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus
ipilimumab's safety and effectiveness in treating resectable NSCLC.

This study has multiple primary endpoints.

The first primary completion date of Pathological Complete Response is anticipated to be
reached April 2020.

The completion date for all primary outcome measures is expected May 2023.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Early stage IB-IIIA, operable non-small cell lung cancer, confirmed in tissue

- Lung function capacity capable of tolerating the proposed lung surgery

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1

- Available tissue of primary lung tumor

Exclusion Criteria:

- Presence of locally advanced, inoperable or metastatic disease

- Participants with active, known or suspected autoimmune disease

- Prior treatment with any drug that targets T cell co-stimulations pathways (such as
checkpoint inhibitors)

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
77
sites
Texas Oncology, PA at South Austin Cancer Center
Austin, Texas 78745
517
mi
from
Austin, TX
Click here to add this to my saved trials
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland 21231
410-955-6190
Phone: 410-502-8737
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
1149
mi
from
Baltimore, MD
Click here to add this to my saved trials
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Phone: 617-632-3468
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
1444
mi
from
Boston, MA
Click here to add this to my saved trials
Fort Wayne Medical Oncology and Hematology
11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Phone: 260-969-7876
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
718
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-322-4967
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
618
mi
from
Nashville, TN
Click here to add this to my saved trials
Orlando Health
24 Sturtevant St
Orlando, Florida 32806
Phone: 321-841-3812
1142
mi
from
Orlando, FL
Click here to add this to my saved trials
Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Phone: 503-418-9389
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
1383
mi
from
Portland, OR
Click here to add this to my saved trials
Indian River Med. Ctr.
1000 36th Street
Vero Beach, Florida 32960
Phone: 772-226-4960
1227
mi
from
Vero Beach, FL
Click here to add this to my saved trials
Local Institution
Athens, Georgia 30607
842
mi
from
Athens, GA
Click here to add this to my saved trials
Medstar Franklin Sqaure Medical Center
Baltimore, Maryland 21237
Phone: 443-777-7364
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Texas Oncology, P.A.
Bedford, Texas 76022
Phone: 817-359-9000
342
mi
from
Bedford, TX
Click here to add this to my saved trials
St. Vincent Frontier Cancer Center
Billings, Montana 59102
Phone: 406-238-6290
780
mi
from
Billings, MT
Click here to add this to my saved trials
Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Phone: 617-632-4767
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
1444
mi
from
Boston, MA
Click here to add this to my saved trials
The University of Vermont Cancer Center
Burlington, Vermont 05405
Phone: 802-656-9916
1357
mi
from
Burlington, VT
Click here to add this to my saved trials
Instituto Medico Especializado Alexander Fleming
Capital Federal, Buenos Aires
Phone: +541132218956
?
mi
from
Capital Federal,
Click here to add this to my saved trials
Charleston Hematology/Oncology Associates, Pa
Charleston, South Carolina 29403
Phone: 843-577-6957
1062
mi
from
Charleston, SC
Click here to add this to my saved trials
Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-4421
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
1063
mi
from
Charleston, SC
Click here to add this to my saved trials
University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Phone: 773-702-1280
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
609
mi
from
Chicago, IL
Click here to add this to my saved trials
Northwestern Medicine
Chicago, Illinois 60611
Phone: 312-695-4781
610
mi
from
Chicago, IL
Click here to add this to my saved trials
The Christ Hospital
2139 Auburn Ave
Cincinnati, Ohio 45219
(513) 585-2000
Phone: 513-451-4033
The Christ Hospital For more than 120 years, The Christ Hospital has been a leader...
725
mi
from
Cincinnati, OH
Click here to add this to my saved trials
MetroHealth Med Ctr
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
Phone: 216-778-3526
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
895
mi
from
Cleveland, OH
Click here to add this to my saved trials
Local Institution
Columbia, Missouri 65212
308
mi
from
Columbia, MO
Click here to add this to my saved trials
University of Miami
Deerfield Beach, Florida 33442
Phone: 954-698-3616
1298
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
Rocky Mountain Cancer Center
Denver, Colorado 80218
Phone: 303-285-5081
408
mi
from
Denver, CO
Click here to add this to my saved trials
Henry Ford Health System
Detroit, Michigan 48202
Phone: 313-916-0482
841
mi
from
Detroit, MI
Click here to add this to my saved trials
WBAMC Oncology Department
El Paso, Texas 79920
Phone: 915-742-3432
?
mi
from
El Paso, TX
Click here to add this to my saved trials
Local Institution
Elizabethtown, Kentucky 42701
653
mi
from
Elizabethtown, KY
Click here to add this to my saved trials
Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-208-3173
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
1114
mi
from
Fairfax, VA
Click here to add this to my saved trials
Local Institution
32 Washington Street
Fairhaven, Massachusetts 02719
1449
mi
from
Fairhaven, MA
Click here to add this to my saved trials
Local Institution
Fort Gordon, Georgia 30905
?
mi
from
Fort Gordon, GA
Click here to add this to my saved trials
Local Institution
Fort Worth, Texas 76164
344
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Local Institution
Fredericksburg, Virginia 22408
?
mi
from
Fredericksburg, VA
Click here to add this to my saved trials
Bon Secours St. Francis Hospital
Greenville, South Carolina 29601
879
mi
from
Greenville, SC
Click here to add this to my saved trials
The Cancer Center, Hackensack University Medical Center
Hackensack, New Jersey
Phone: 551-996-8066
1285
mi
from
Hackensack, NJ
Click here to add this to my saved trials
Hattiesburg Clinic
Hattiesburg, Mississippi 39401
Phone: 601-288-2495
659
mi
from
Hattiesburg, MS
Click here to add this to my saved trials
Local Institution
High Point, North Carolina 27262
991
mi
from
High Point, NC
Click here to add this to my saved trials
Memorial Regional Hospital
Hollywood, Florida 33021
1309
mi
from
Hollywood, FL
Click here to add this to my saved trials
Local Institution
Houston, Texas 77030
572
mi
from
Houston, TX
Click here to add this to my saved trials
Millenium Oncology
Houston, Texas 77090
Phone: 877-870-2640
551
mi
from
Houston, TX
Click here to add this to my saved trials
New York Oncology Hematology, Pc
Irving, Texas 75063
?
mi
from
Irving, TX
Click here to add this to my saved trials
Local Institution
Jacksonville, Florida 32256
1065
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
970
mi
from
Las Vegas, NV
Click here to add this to my saved trials
University of Kentucky
Lexington, Kentucky
859) 257-9000
Phone: 859-218-6145
University of Kentucky The University of Kentucky is a public, land grant university dedicated to...
725
mi
from
Lexington, KY
Click here to add this to my saved trials
Los Angeles Hematology/Oncology Medical Group
Los Angeles, California 90017
Phone: 213-977-1214
1169
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Local Institution
Los Angeles, California 90095
1179
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Local Institution
Louisville, Kentucky 40202
657
mi
from
Louisville, KY
Click here to add this to my saved trials
Local Institution
Lubbock, Texas
366
mi
from
Lubbock, TX
Click here to add this to my saved trials
Northwest Georgia Oncology Center
Marietta, Georgia 30060
Phone: 770-333-2161
787
mi
from
Marietta, GA
Click here to add this to my saved trials
Intermountain Medical Center
5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Phone: 801-507-3950
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
779
mi
from
Murray, UT
Click here to add this to my saved trials
Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
558
mi
from
Nashville, TN
Click here to add this to my saved trials
University Medical Center New Orleans
New Orleans, Louisiana 70112
Phone: 504-702-5171
697
mi
from
New Orleans, LA
Click here to add this to my saved trials
Local Institution
New York, New York 10016
1288
mi
from
New York, NY
Click here to add this to my saved trials
Laura And Isaac Perlmutter Cancer Center
New York, New York 10016
Phone: 212-263-8696
1288
mi
from
New York, NY
Click here to add this to my saved trials
Illinois Cancer Specialists
Niles, Illinois 60714
Phone: 847-827-9060
606
mi
from
Niles, IL
Click here to add this to my saved trials
Cancer Institute Of Florida
Orlando, Florida 32804
Phone: 407-303-2523
1139
mi
from
Orlando, FL
Click here to add this to my saved trials
Local Institution
Philadelphia, Pennsylvania 19102
1225
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Phone: 215-214-3789
1229
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Arizona Oncology Assoc, Pc-Hal
Phoenix, Arizona 85016
Phone: 602-277-4868
848
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Local Institution
Phoenix, Arizona 85016
849
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Local Institution
Pittsburgh, Pennsylvania 15240
977
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Allegheny General Hospital
320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Phone: 412-578-1364
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
971
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Cancer Center of Central Connecticut
Plainville, Connecticut
Phone: 860-224-4408
1349
mi
from
Plainville, CT
Click here to add this to my saved trials
Local Institution
Portland, Oregon 97201
1384
mi
from
Portland, OR
Click here to add this to my saved trials
Local Institution
Sacramento, California 95819
1280
mi
from
Sacramento, CA
Click here to add this to my saved trials
Local Institution
1506 South Silicon Way
Saint George, Utah 84770
866
mi
from
Saint George, UT
Click here to add this to my saved trials
Southwest Regional Cancer Clinic
544 South 400 East
Saint George, Utah 84770
Phone: 435-688-4168
864
mi
from
Saint George, UT
Click here to add this to my saved trials
Huntsman Cancer Institute
Salt Lake City, Utah 84112
Phone: 801-587-4368
777
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Local Institution
Santa Barbara, California 93105
1239
mi
from
Santa Barbara, CA
Click here to add this to my saved trials
Local Institution
Santa Rosa, California 95403
1351
mi
from
Santa Rosa, CA
Click here to add this to my saved trials
Texas Cancer Center - Sherman
Sherman, Texas 75090
292
mi
from
Sherman, TX
Click here to add this to my saved trials
Local Institution
8007 183rd Street
Tinley Park, Illinois 60487
593
mi
from
Tinley Park, IL
Click here to add this to my saved trials
HOPE Cancer Center of East Texas
721 Clinic Drive
Tyler, Texas 75701
Phone: 903-595-7045
400
mi
from
Tyler, TX
Click here to add this to my saved trials
Texas Oncology
Waco, Texas 76712
430
mi
from
Waco, TX
Click here to add this to my saved trials
Valley Hospital Luckow Pavili
1 Valley Health Plaza
Westwood, New Jersey 07675
Phone: 201-634-5792
1283
mi
from
Westwood, NJ
Click here to add this to my saved trials
Local Institution
Wichita, Kansas 67214
27
mi
from
Wichita, KS
Click here to add this to my saved trials
Local Institution
Worcester, Massachusetts 01608
1405
mi
from
Worcester, MA
Click here to add this to my saved trials
Genesis Health Care System
740 Adair Avenue
Zanesville, Ohio 43701
862
mi
from
Zanesville, OH
Click here to add this to my saved trials