Sapanisertib in Treating Patients With Metastatic or Refractory Pancreatic Neuroendocrine Tumor That Cannot Be Removed by Surgery



Status:Suspended
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/17/2019
Start Date:February 1, 2017
End Date:August 1, 2019

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A Phase II Study of MLN0128 (TAK-228) in Rapalog-Resistant Advanced Pancreatic Neuroendocrine Tumors (PNET)

This phase II trial studies how well sapanisertib works in treating patients with pancreatic
neuroendocrine tumor that has spread to other places in the body, does not respond to
treatment, or cannot be surgically removed. Drugs such as sapanisertib may stop the growth or
shrink tumor cells by blocking some of the enzymes needed for cell growth.

PRIMARY OBJECTIVES:

I. To evaluate overall response rate associated with sapanisertib (MLN0128 [TAK-228]) in
patients with advanced pancreatic neuroendocrine tumors (PNETs).

SECONDARY ENDPOINTS:

I. To evaluate progression-free survival (PFS) associated with MLN0128 (TAK-228) in patients
with advanced pancreatic neuroendocrine tumors (PNETs).

II. To measure the safety and tolerability of MLN0128 (TAK-228) in patients with advanced
PNETs.

III. To evaluate disease control rate associated with MLN0128 (TAK-228) in patients with
advanced PNETs.

IV. To measure duration of response rate associated with MLN0128 (TAK-228) in patients with
advanced PNETs.

OUTLINE:

Patients receive sapanisertib orally (PO) once daily (QD) on days 1-28. Courses repeat every
28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 1 year, and then yearly for 2 years.

Inclusion Criteria:

- Patients must have unresectable or metastatic, histologically confirmed low or
intermediate grade (Klimstra Criteria) pancreatic neuroendocrine tumor (PNET) with
radiological evidence of disease progression since last treatment

- Refractory disease to treatment with an mTOR inhibitor

- Patients with uncontrolled intercurrent illness including, but not limited to, ongoing
or active infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements, are ineligible

- Disease that is currently not amenable to surgery, radiation, or combined modality
therapy with curative intent

- Patients must not have poorly differentiated neuroendocrine carcinoma, high-grade
neuroendocrine carcinoma, adenocarcinoid, goblet cell carcinoid and small cell
carcinoma

- Patients must have measurable disease

- Documented radiological evidence for disease progression (measurable or nonmeasurable)
=< 12 months prior to enrollment

- NOTE: If patient has had previous radiation to the marker lesion(s), there must
be evidence of progression since the radiation; at least one measurable lesion as
per Response Evaluation Criteria in Solid Tumors (RECIST)

- Prior or concurrent therapy with SSA is permitted; a stable dose at least 2 months
prior to study start and must continue on the stable dose while receiving study
treatment; SSA is not considered as systemic treatment

- Recovered from adverse events to grade 1 or less toxicity according to Common
Terminology Criteria for Adverse Events version 4.0 (CTCAE 4.0) due to agents
administered previously

- NOTE: Chemotherapy-induced alopecia and grade 2 neuropathy are acceptable

- Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

- Patients must be able to swallow intact capsules

- Within less than or equal to 14 days prior to registration: Leukocytes >= 3,000/mm^3

- Within less than or equal to 14 days prior to registration: Absolute neutrophil count
(ANC) >= 1.5 x 10^9/L

- Within less than or equal to 14 days prior to registration: Hemoglobin >= 10 g/dL

- Within less than or equal to 14 days prior to registration: Platelets >= 100 x 10^9/L

- Within less than or equal to 14 days prior to registration: Total serum bilirubin =<
institutional upper limit of normal (ULN)

- Within less than or equal to 14 days prior to registration: Alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN

- Within less than or equal to 14 days prior to registration: Serum creatinine =< 1.5 X
institutional ULN and creatinine clearance >= 60 ml/min

- NOTE: Creatinine clearance must be calculated using the Cockcroft-Gault equation

- Within less than or equal to 14 days prior to registration: Glycosylated hemoglobin
(HbA1c) < 7.0%

- Within less than or equal to 14 days prior to registration: Fasting serum glucose =<
130 mg/dL

- Within less than or equal to 14 days prior to registration: Fasting triglycerides =<
300 mg/dL

- Diabetics are allowed if:

- Fasting blood glucose (FBG) =< 130 mg/dL (mmol/L), OR

- HbA1c =< 7%

- Women must not be pregnant or breast-feeding; all females of childbearing potential
must have a blood test or urine study within 7 days of registration to rule out
pregnancy; a female of childbearing potential is any woman, regardless of sexual
orientation or whether they have undergone tubal ligation, who meets the following
criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not
been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses
at any time in the preceding 24 consecutive months)

- Women of child-bearing potential and men must agree to practice 1 highly effective
method of contraception and 1 additional effective (barrier) method of contraception,
at the same time, from the time of signing the informed consent through 90 days (for
female patients) and 120 day (for male patients) after the last dose of study drug, or
agree to completely abstain from heterosexual intercourse; should a woman become
pregnant or suspect she is pregnant while she or her partner is participating in this
study, she should inform her treating physician immediately; men must agree not to
donate sperm during the course of this study or within 120 days after receiving their
last dose of study drug

- Patient is INELIGIBLE if patient discontinued prior mTOR inhibitor due to toxicity

- Patients must NOT have radiotherapy, or major surgery or active drug therapy for pNET
(SSA permitted) within 4 weeks prior to study treatment start

- Patient must NOT have had previous treatment with any PI3K or AKT inhibitor

- NO hepatic artery embolization or cryoablation/radiofrequency ablation of hepatic
metastasis within 2 months of study treatment start

- Patients must NOT have previous or concurrent malignancy within 2 years; exceptions
are made for patients who meet any of the following conditions:

- Adequately treated basal cell or squamous cell skin cancer, superficial bladder
cancer OR

- Adequately treated stage I or II cancer currently in complete remission, or any
other cancer that has been in complete remission for at least 2 years

- No more than 3 prior systemic treatment regimens for advanced PNET

- Patients with a history of the following within =< 6 months of study entry are NOT
eligible:

- Ischemic myocardial event, including angina requiring therapy and artery
revascularization procedures

- Ischemic cerebrovascular event, including transient ischemic attack (TIA) and
artery revascularization procedures

- Requirement for inotropic support (excluding digoxin) or serious (uncontrolled)
cardiac arrhythmia (including atrial flutter/fibrillation, ventricular
fibrillation or ventricular tachycardia)

- New York Heart Association (NYHA) class III or IV heart failure

- Pulmonary embolism

- Patients with known significant active cardiovascular or pulmonary disease at the time
of study entry are INELIGIBLE including:

- Uncontrolled hypertension (i.e., systolic blood pressure >180 mm Hg, diastolic
blood pressure > 95 mm Hg); use of anti-hypertensive agents to control
hypertension before cycle1 day 1 is allowed

- Pulmonary hypertension

- Uncontrolled asthma or oxygen (O2) saturation < 90% by arterial blood gas
analysis or pulse oximetry on room air

- QT syndrome, or torsades de pointes

- Significant valvular disease; severe regurgitation or stenosis by imaging
independent of symptom control with medical intervention, or history of valve
replacement

- Medically significant (symptomatic) bradycardia

- History of arrhythmia requiring an implantable cardiac defibrillator

- Baseline prolongation of the rate-corrected QT interval (QTc) (e.g., repeated
demonstration of QTc interval > 480 milliseconds, or history of congenital long

- Patients with known manifestations of malabsorption due to prior gastrointestinal (GI)
surgery, GI disease, or for an unknown reason that may alter the absorption of MLN0128
(TAK-228) are INELIGIBLE

- Patients who have a history of brain metastasis are eligible for the study provided
that all the following criteria are met:

- Brain metastases which have been treated

- No evidence of disease progression for >= 3 months before the first dose of study
drug

- No hemorrhage after treatment

- Off-treatment with dexamethasone for 4 weeks before administration of the first
dose of TAK-228

- No ongoing requirement for dexamethasone or anti-epileptic drugs

- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral
therapy are INELIGIBLE

- NO treatment with strong inhibitors and/or inducers of cytochrome P450 (CYP) 3A4, or
CYP2C19 within 1 week preceding the first dose of study drug

- NO patients receiving systemic corticosteroids (either intravenous [IV] or oral
steroids, excluding inhalers or low-dose hormone replacement therapy) within 1 week
before administration of the first dose of study drug

- Patients CANNOT have daily or chronic use of a proton pump inhibitor (PPI) and/or
having taken a PPI within 7 days before receiving the first dose of study drug

- Voluntary written consent must be given before performance of any study related
procedure not part of standard medical care, with the understanding that consent may
be withdrawn by the patient at any time without prejudice to future medical care
We found this trial at
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(515) 358-9700
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
Mercy Cancer Center - West Lakes When it comes to cancer care, there
573
mi
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Clive, IA
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Cody, Wyoming 82414
Principal Investigator: Benjamin T. Marchello
Phone: 800-996-2663
1361
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Cody, WY
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Coeur d'Alene, Idaho 83814
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
1748
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Coeur d'Alene, ID
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6001 E Woodmen Rd
Colorado Springs, Colorado 80923
(719) 776-5000
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
1163
mi
from 43215
Colorado Springs, CO
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Colorado Springs, Colorado 80907
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
1162
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Colorado Springs, CO
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1400 East Boulder Street
Colorado Springs, Colorado 80909
1162
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Colorado Springs, CO
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Columbus, Ohio 43210
Principal Investigator: Manisha H. Shah
Phone: 800-293-5066
2
mi
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Columbus, OH
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4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
(763) 236-6000
Principal Investigator: David M. King
Phone: 952-993-1517
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
634
mi
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Coon Rapids, MN
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Corbin, Kentucky 40701
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
216
mi
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Corbin, KY
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Council Bluffs, Iowa 51503
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
678
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Council Bluffs, IA
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Creston, Iowa 50801
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
599
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Creston, IA
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Danville, Illinois 61832
Principal Investigator: Suparna Mantha
Phone: 800-446-5532
243
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Danville, IL
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Davis, California 95616
Principal Investigator: Stacy D. D'Andre
Phone: 415-209-2686
2057
mi
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Davis, CA
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1 Wyoming St,
Dayton, Ohio 45409
(937) 208-8000
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital Miami Valley Hospital (MVH) is passionate about providing the most recent medical...
64
mi
from 43215
Dayton, OH
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2222 Philadelphia Dr
Dayton, Ohio 45406
(937) 734-2612
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
63
mi
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Dayton, OH
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Dayton, Ohio 45415
63
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Dayton, OH
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63
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Dayton, OH
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Dearborn, Michigan 48124
Principal Investigator: Tareq Al Baghdadi
Phone: 208-367-7954
161
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Dearborn, MI
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2300 N Edward St
Decatur, Illinois 62526
(217) 876-8121
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
314
mi
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Decatur, IL
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210 West McKinley Avenue
Decatur, Illinois 62526
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
314
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Decatur, IL
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115 10th Avenue Northeast
Deer River, Minnesota 56636
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
740
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Deer River, MN
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2525 S Downing St
Denver, Colorado 80210
(303) 778-1955
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
Porter Adventist Hospital Founded in 1930, Porter Adventist Hospital has provided people throughout Denver and...
1161
mi
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Denver, CO
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