The Influence of Regular Beef Consumption and Protein Density of the Diet on Training-induced Gains in Muscle Strength and Performance in Healthy Adults
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 40 - 64 |
| Updated: | 5/3/2018 |
| Start Date: | February 1, 2017 |
| End Date: | September 2019 |
Humans lose muscle and strength as they get older. Further, ageing is accompanied by loss in
cognitive function. It is not quite clear why this happens; however, it is known that the
loss of muscle and strength can increase risk for physical and mental health risks and impair
the ability of older people to remain physically independent. Weight lifting and proper
nutrition, particularly eating high quality protein at the proper time and quantity, may help
prevent these losses when a person gets older. To determine if regular beef consumption as
part of a higher protein diet aids the muscle adaptive response to resistance training and
improvements in cognition, seventy healthy individuals will be recruited to lift weights 3
times a week for 10 weeks. One group (n=36) will consume the Recommended Dietary Allowance
(RDA) for protein (0.8g/kg/day), while the other group (n=36) will consume an amount twice
the RDA (1.6g/kg/day), which is in agreement with recommendations from the American College
of Sports Medicine. Participants will have their muscle strength tested and samples of blood
and muscles will be collected before and after training to determine how the muscle adaptive
response to resistance exercise is affected by higher protein intake. In addition,
participants will undergo cognitive assessments at baseline and follow-up to determine the
influence of improving muscle strength on attention and memory. Overall, the investigators
proposed study will use sensitive methodology to determine if providing protein above the RDA
and at optimal times during the day in combination with a weight lifting program can help
make someone stronger and build larger muscles than someone consuming the RDA, as well as
what processes may be responsible for helping the muscles to get bigger and stronger.
cognitive function. It is not quite clear why this happens; however, it is known that the
loss of muscle and strength can increase risk for physical and mental health risks and impair
the ability of older people to remain physically independent. Weight lifting and proper
nutrition, particularly eating high quality protein at the proper time and quantity, may help
prevent these losses when a person gets older. To determine if regular beef consumption as
part of a higher protein diet aids the muscle adaptive response to resistance training and
improvements in cognition, seventy healthy individuals will be recruited to lift weights 3
times a week for 10 weeks. One group (n=36) will consume the Recommended Dietary Allowance
(RDA) for protein (0.8g/kg/day), while the other group (n=36) will consume an amount twice
the RDA (1.6g/kg/day), which is in agreement with recommendations from the American College
of Sports Medicine. Participants will have their muscle strength tested and samples of blood
and muscles will be collected before and after training to determine how the muscle adaptive
response to resistance exercise is affected by higher protein intake. In addition,
participants will undergo cognitive assessments at baseline and follow-up to determine the
influence of improving muscle strength on attention and memory. Overall, the investigators
proposed study will use sensitive methodology to determine if providing protein above the RDA
and at optimal times during the day in combination with a weight lifting program can help
make someone stronger and build larger muscles than someone consuming the RDA, as well as
what processes may be responsible for helping the muscles to get bigger and stronger.
Inclusion Criteria:
- Non-obese adults: BMI <30 kg/m2
- Aged between 40-64 years
- Sedentary
- Weight-stable for 6 months prior
Exclusion Criteria:
- Allergies to beef consumption
- Phenylketonuria (PKU)
- BMI >30 kg/m2
- history of active cardiovascular disease, diabetes mellitus, GI disorders,
musculoskeletal/orthopedic disorders (e.g. osteoarthritis, rheumatoid arthritis,
tendinitis, gout, fibromyalgia, patellar tendinopathy, or chronic low back pain)
- hypersensitivity or allergy to antibiotics
- Kidney, urinary, or liver conditions
- Epilepsy
- Diagnosed mental illness
- have bleeding or clotting disorders (or take related medications e.g.. Coumadin/ low
dose Aspirin)
- High alcohol consumption
- use tobacco
- uncontrolled hypertension
- vegan/vegetarian diets
- on medications known to affect protein metabolism (i.e. corticosteroids,
androgen/estrogen containing compounds, non-steroidal anti-inflammatories)
- habitual consumption of high (>1.8 g protein/kg/d) or low (<0.66 g protein/kg/day)
- pregnancy
- supplements that influence protein metabolism (e.g. omega 3 fish oils)
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