Partners Calciphylaxis Biobank

Calciphylaxis, a vascular calcification disorder, is a rare and serious disorder
characterized by calcification of dermal arterioles.

There are significant gaps in the understanding of the pathophysiology and risk factors for
calciphylaxis. At present, there is no effective treatment. Uncertain pathobiology, rare
incidence and lack of collaborative approach have been some of the major limiting factors
towards treating calciphylaxis.

The Partners Calciphylaxis Biorepository (PCB) aims to address these gaps within
calciphylaxis research by utilizing existing and, when necessary, developing new
infrastructure to support the consent of patients and the collection of dedicated samples for
a calciphylaxis repository.

This repository is working in collaboration with the Partners Biobank as they will still be
receiving samples from the PCB and storing them and distributing them according to their own
procedures.

Inclusion Criteria:

1. Male or female ≥18 years old

2. Skin lesions consistent with calciphylaxis diagnosis as determined by the treating
clinician

3. Informed of the investigational nature of the study and sign written Informed consent
OR are eligible for surrogate consent process based on impaired decision making

Exclusion Criteria:

1. Patients <18 years of age

2. Prisoners