Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia

The investigators plan a prospective, multi-center study to determine if liver ultrasound
shear wave speed measurements acquired at clinical presentation can discriminate biliary
atresia (BA) from other causes of liver disease in the setting of neonatal cholestasis. The
investigators also plan to determine if liver ultrasound shear wave speed measurements
acquired at clinical presentation or longitudinally during the first one-year period after
Kasai can predict important long-term outcomes in BA patients.

Inclusion Criteria:

- neonatal cholestasis with concern for BA vs. other liver disease direct bilirubin >20%
of total or ≥2 mg/dL age <3 months

Exclusion Criteria:

- inability to obtain parent/guardian consent.

- inability to return for follow up visits as required by the study (these patients will
be included in aim 1, but will be unable to participate in aim 2).

- no other exclusion criteria.