Protein and Phospholipid Analysis of HDL in Patients With Very High Serum Levels of HDL-C
| Status: | Recruiting |
|---|---|
| Conditions: | High Cholesterol |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/11/2015 |
| Start Date: | June 2005 |
| End Date: | June 2016 |
| Contact: | Sergio Fazio, MD |
| Email: | sergio.fazio@vanderbilt.edu |
| Phone: | 615-936-1450 |
Coronary heart disease (CHD) is the single leading cause of death in the United States .
Serum Cholesterol is known to have a direct impact on a number of human diseases through a
variety of mechanisms. This is particularly true of cardiovascular disease. Measurement
and manipulation of serum cholesterol has become a primary focus of primary care physicians
and cardiologists when attempting to reduce risk of heart disease.
Serum Cholesterol is known to have a direct impact on a number of human diseases through a
variety of mechanisms. This is particularly true of cardiovascular disease. Measurement
and manipulation of serum cholesterol has become a primary focus of primary care physicians
and cardiologists when attempting to reduce risk of heart disease.
Clinical investigations have shown that lowering the "total serum cholesterol" levels result
in a significant reduction of coronary artery disease and myocardial infarctions . Thus,
interventions to lower the "total serum cholesterol" are commonly employed by medical
professionals - this includes behavioral modifications (exercise, dieting, and weight loss)
and pharmacological interventions.
Investigation has shown that clinical outcomes do not only rely on "total serum
cholesterol". "Total serum cholesterol" is comprised of multiple subtypes - most notable
are "HDL Cholesterol" and "LDL cholesterol". Analysis of the data has shown that high
levels of LDL cholesterol predict higher rates of cardiovascular events, while high levels
of HDL cholesterol are actually predictive of significantly less cardiovascular events.
These effects are independent of other cardiovascular risk factors .
The mechanism by which LDL cholesterol results in heart disease has been intensely
investigated and elucidated. Numerous drugs are now approved and utilized by physicians to
lower the LDL cholesterol of patients to prevent primary and secondary cardiovascular
disease.
Epidemiological data show that low levels of HDL-C place individuals at higher risk for
coronary artery disease while high levels of HDL-C actually decrease an individual's risk .
The mechanism behind this risk reduction remains unclear and is likely multi-factorial.
Furthermore, some data suggests that while HDL-C is important in risk reduction, it is not
necessarily the measured serum level of HDL-C, but also the composition, oxidation state,
metabolism of the HDL-C that determines an individual's cardiac risk . Understanding of
this mechanism could lead to potential therapeutic targets as well as clinically relevant
diagnostic testing.
in a significant reduction of coronary artery disease and myocardial infarctions . Thus,
interventions to lower the "total serum cholesterol" are commonly employed by medical
professionals - this includes behavioral modifications (exercise, dieting, and weight loss)
and pharmacological interventions.
Investigation has shown that clinical outcomes do not only rely on "total serum
cholesterol". "Total serum cholesterol" is comprised of multiple subtypes - most notable
are "HDL Cholesterol" and "LDL cholesterol". Analysis of the data has shown that high
levels of LDL cholesterol predict higher rates of cardiovascular events, while high levels
of HDL cholesterol are actually predictive of significantly less cardiovascular events.
These effects are independent of other cardiovascular risk factors .
The mechanism by which LDL cholesterol results in heart disease has been intensely
investigated and elucidated. Numerous drugs are now approved and utilized by physicians to
lower the LDL cholesterol of patients to prevent primary and secondary cardiovascular
disease.
Epidemiological data show that low levels of HDL-C place individuals at higher risk for
coronary artery disease while high levels of HDL-C actually decrease an individual's risk .
The mechanism behind this risk reduction remains unclear and is likely multi-factorial.
Furthermore, some data suggests that while HDL-C is important in risk reduction, it is not
necessarily the measured serum level of HDL-C, but also the composition, oxidation state,
metabolism of the HDL-C that determines an individual's cardiac risk . Understanding of
this mechanism could lead to potential therapeutic targets as well as clinically relevant
diagnostic testing.
Inclusion Criteria:
- Age > 18 years.
- Serum HDL-C > 100 mg/dL.
Exclusion Criteria:
- Significant history of smoking.
- Diabetes Mellitus.
- Severe hypertension.
- Age > 65 years
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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