Study to Evaluate the Effect of ALS-008176 on Cardiac Repolarization Interval in Healthy Participants

This is a two-part Phase 1 study consisting of a dose escalation part (Part 1) and a TQT part
(Part 2), performed in two separate panels (Panels 1 and 2). Panel 1 will be a double blind
(neither the researchers nor the participants know what treatment the participant is
receiving), randomized (study medication assigned to participants by chance), placebo
controlled dose escalation study in healthy participants to determine the safety,
tolerability and pharmacokinetics of ALS-008176 after administration of single doses of 1500
milligrams (mg), 2500 mg and 3000 mg under fasted conditions. The final dose to be used in
the Panel 2 will be determined based on the results of this dose escalation part. An interim
analysis will be conducted on Panel 1 to select the dose for Panel 2. Panel 2 will be a
double blind, double dummy, randomized, 3 period crossover (the same medications provided to
all participants but in different sequence), placebo and positive controlled study to
evaluate the effect of ALS-008176 on the QT/QTc interval in healthy participants.
Participants' safety will be monitored throughout the study.

Inclusion Criteria:

- Each participant must sign an informed consent form (ICF) indicating that he or she
understands the purpose of and procedures required for the study and is willing to
participate in the study

- Participant must be willing and able to adhere to the prohibitions and restrictions
specified in protocol

- A female participant must be of non-childbearing potential, defined as either: a)
Postmenopausal- A postmenopausal state is defined as no menses for at least 12 months
without an alternative medical cause and a serum follicle stimulating hormone (FSH)
level in the postmenopausal range (> 40 International units per liter [IU/L] or
International units/milliliter [mIU/mL]); b) Permanently sterile- Permanent
sterilization methods include hysterectomy, bilateral salpingectomy, bilateral tubal
occlusion/ligation procedures (without reversal operation), and bilateral oophorectomy

- During the study and for a minimum of one spermatogenesis cycle (defined as
approximately 90 days) after receiving the (last dose of) study drug, a male
participant: a) who is sexually active with a woman of childbearing potential must
agree to use a barrier method of contraception (example, condom with spermicidal
foam/gel/film/cream/suppository); b) who is sexually active with a pregnant woman must
use a condom; c) must agree not to donate sperm

- Female partners of male participants must either be surgically sterilized,
postmenopausal (amenorrhea for a minimum of 1 year) or, if of childbearing potential,
must agree to use at least one of the following contraceptive methods for 90 days
following the last dose of study drug: a nonhormonal intrauterine device with
spermicide; contraceptive sponge with spermicide, diaphragm with spermicide, cervical
cap with spermicide, or oral, implantable, transdermal, or injectable hormonal
contraceptives

- A female participant must have a negative serum beta human chorionic gonadotropin
(b-hCG) pregnancy test at screening and on Day -1

- A female participant must agree not to donate eggs (ova, oocytes) during the study and
for at least 90 days after receiving the (last dose of) study drug

- Participants must have a body mass index (BMI); weight (kilogram [kg])/height^2 (meter
[m]^2) between 18.0 and 30.0 kg/m^2 (inclusive) at screening

- Participants must have a blood pressure (supine after at least 5 minutes rest) between
90 and 140 millimeters of Mercury (mmHg) systolic, inclusive, and no higher than 90
mmHg diastolic at screening

- Participants must have a 12-lead electrocardiogram (ECG) consistent with normal
cardiac conduction and function at screening, including: a) Sinus rhythm (heart rate
between 45 and 100 beats per minute (bpm), inclusive); b) QT interval corrected for
heart rate according to Fridericia (QTcF) interval between 350 milliseconds (ms) and
430 ms for male participants, and between 350 ms and 450 ms for female participants
(inclusive); c) QRS interval of <110 ms; d) PR interval <=200 ms; e) Morphology
consistent with healthy cardiac conduction and function

- Participants must be non-smokers for at least 3 months prior to screening

- Participants must be healthy on the basis of a medical evaluation that reveals the
absence of any clinically significant abnormality and includes a complete physical
examination, medical and surgical history, vital signs, ECGs, and the results of blood
biochemistry and hematology tests and a urinalysis performed at screening. If there
are abnormalities the participant may be included only if the Investigator judges the
abnormalities or deviations from normal to be not clinically significant. This
determination must be recorded in the participant's source documents and initialed by
the Investigator

- Participants must have normal values for alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) (<= 1.0*upper limit of laboratory normal range [ULN])

Exclusion Criteria:

- Participants has a history of current clinically significant medical illness including
(but not limited to) cardiac arrhythmias or other cardiac disease, hematologic
disease, coagulation disorders (including any abnormal bleeding or blood dyscrasias),
lipid abnormalities, significant pulmonary disease, including bronchospastic
respiratory disease, diabetes mellitus, hepatic or renal insufficiency, thyroid
disease, neurologic or psychiatric disease, infection, or any other illness that the
Investigator considers should exclude the participant or that could interfere with the
interpretation of the study results

- Participants with one or more laboratory abnormalities at screening as defined in the
Protocol

- Participants with a history of clinically relevant heart rhythm disturbances including
atrial, junctional, re-entry, and ventricular tachycardias, heart blocks and
incomplete and complete right and left bundle branch blocks

- Participants with unusual T wave morphology (such as bifid T wave) likely to interfere
with QTc measurements

- Participants with a past history of heart arrhythmias (extra systolic beats or
tachycardia at rest) or with a history of risk factors for Torsade de Pointes syndrome
(for example, hypokalemia or family history of short/long QT syndrome, or sudden
unexplained death at a young age [less than or equal to 40 years], drowning or sudden
infant death in a first degree relative [that is, sibling, offspring, or biological
parent])

- Participants with electrolyte abnormalities (hypokalemia, hypocalcemia,
hypomagnesemia) of grade 2 or above within 21 days prior to the (first) intake of the
study drug

- Participants with any skin condition likely to interfere with ECG electrode placement
or adhesion

- Participants with a breast implant or a history of thoracic surgery likely to cause
abnormality of the electrical conduction through thoracic tissues

- Participants with any history of clinically significant skin disease such as, but not
limited to, dermatitis, eczema, drug rash, psoriasis, food allergy, or urticaria

- Participants with a history of clinically significant drug allergy such as, but not
limited to, sulfonamides and penicillins, or drug allergy diagnosed in previous
studies with experimental drugs

- Participants with presence of any febrile illness or symptoms of upper or lower
respiratory tract infection in the 14 days before the (first) administration of study
drugs

- Participant has taken any disallowed therapies as noted in Concomitant Therapy before
the planned (first) intake of study drug

- Participant has a history of drug or alcohol abuse according to Diagnostic and
Statistical Manual of Mental Disorders (5th edition) (DSM-5) criteria within 5 years
before screening or positive test result(s) for alcohol and/or drugs of abuse
(including barbiturates, opiates, cocaine, amphetamines, methadone, benzodiazepines,
methamphetamine, tetrahydrocannabinol, phencyclidine, and tricyclic antidepressants)
at screening

- Participant has known allergies, hypersensitivity, or intolerance to ALS-008176,
moxifloxacin or its excipients

- Participant has known allergy to heparin or history of heparin-induced
thrombocytopenia

- Participant has donated blood or blood products or had substantial loss of blood (more
than 500 milliliter) within 3 months before the (first) administration of study drug
or intention to donate blood or blood products during the study

- Participant has received an investigational drug (including investigational vaccines)
or used an invasive investigational medical device within 90 days before the planned
(first) intake of study drug

- Participant is a woman who is pregnant or breastfeeding

- Participant is a man who plans to father a child while enrolled in this study or
within 90 days after the (last) intake of study drug, or who is unwilling to use
acceptable methods of contraception as outlined in Protocol

- Participant has a history of hepatitis B surface antigen (HBsAg) or hepatitis C virus
(HCV) antibody positive, or other clinically active liver disease, or tests positive
for HBsAg or anti HCV at screening

- Participant has a history of human immunodeficiency virus type 1 (HIV-1) or HIV-2
infection, or tests positive for HIV-1 or -2 at screening

- The participant has preplanned surgery or procedures that would interfere with the
conduct of the study

- Vulnerable participant (example, incarcerated individuals)

- Participant with lack of good/reasonable venous access

- Participant is an employee of the Investigator or study site with direct involvement
in the proposed study or other studies under the direction of that Investigator or
study site, or a family member of the employees or the Investigator, or an employee of
the Sponsor

- Participant has any condition for which, in the opinion of the Investigator,
participation would not be in the best interest of the participant (example,
compromise the well-being) or that could prevent, limit, or confound the
protocol-specified assessments

- Participant has previously been dosed with ALS-008176 in more than 3 single-dose
studies with ALS-008176

- Participant has previously been dosed with ALS-008176 in a multiple-dose study with
ALS 008176