A Study to Evaluate SAGE-217 in Subjects With Severe Postpartum Depression

Key Inclusion Criteria:

- Subject either must have ceased lactating at screening or, if still lactating or
actively breastfeeding at screening, must agree to temporarily cease giving breast
milk to her infant(s)

- Subject has had a Major Depressive Episode that began no earlier than the third
trimester and no later than the first 4 weeks following delivery, as diagnosed by the
Structured Clinical Interview for DSM-5 Axis I Disorders (SCID-I)

- Subject is ≤ six months postpartum

Key Exclusion Criteria:

- Active psychosis

- Attempted suicide associated with current episode of postpartum depression

- Medical history of seizures

- Medical history of bipolar disorder, schizophrenia, and/or schizoaffective disorder.

Note: suicidal ideation is not an exclusion. Other protocol-defined inclusion/exclusion
criteria may apply.