Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
| Status: | Recruiting |
|---|---|
| Conditions: | Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 25 |
| Updated: | 6/21/2018 |
| Start Date: | January 2017 |
| End Date: | April 2019 |
| Contact: | Rachel Kozink, M.S. |
| Email: | rachel.kozink@duke.edu |
| Phone: | 919-668-2963 |
The purpose of this study is to evaluate reactions to, and choices to self-administer,
cigarette smoke with varying nicotine content among low-frequency, non-dependent
adolescent/young adult smokers between the ages of 18-25 years.
cigarette smoke with varying nicotine content among low-frequency, non-dependent
adolescent/young adult smokers between the ages of 18-25 years.
Participants will undergo three sessions in which their reactions to fixed doses of smoke
from investigational cigarettes with three different nicotine contents (15.8 mg/gram of
tobacco, 2.5 mg/g, and .4 mg/g) will be assessed. Following the third fixed-dose session,
participants will return to the lab to choose one of the cigarettes to self-administer.
from investigational cigarettes with three different nicotine contents (15.8 mg/gram of
tobacco, 2.5 mg/g, and .4 mg/g) will be assessed. Following the third fixed-dose session,
participants will return to the lab to choose one of the cigarettes to self-administer.
Inclusion Criteria:
- generally healthy
- between the ages of 18-25
- use nicotine or tobacco products between 1-15 days/month for at least 6 months
- smokes at least 10 cigarettes/month
- no unstable or significant medical or psychiatric conditions
- breath alcohol value=0.000
- able to provide contact information for two individuals who can corroborate smoking
status
Exclusion Criteria:
- use of illegal drugs as measured by urine drug screen (excluding THC)
- serious quit attempt in the past 3 months
- plans to quit smoking in the next 2 months
- current use of nicotine replacement therapy or other tobacco cessation products
- inability to attend all required experimental sessions
- blood pressure >160/100 mmHg
- pregnant, trying to become pregnant, or breastfeeding
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