Study Of Asthma And Genetics In Patients To Be Treated With Fluticasone Propionate/Salmeterol Or Salmeterol Xinafoate



Status:Completed
Conditions:Asthma
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:12 - Any
Updated:2/4/2017
Start Date:October 2004
End Date:January 2007

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Trial Summary
Trial Overview
Inclusion Criteria

Randomized, Double-Blind Comparison of Advair 100/50 BID vs Salmeterol BID vs Albuterol QID in Subjects With ARG/ARG Genotype 12 Years of Age and Older With Presistent Asthma on Short-Acting Beta2-Agonists Alone

This study may last up to 36-38 weeks. Patients will visit the clinic 11 times. A blood
sample will be taken at Visit 1 to look at subjects' genes. Breathing tests will be done
during the study. Study medicines and procedures will be provided at no cost. Patients will
be treated with VENTOLIN (8 wks), ATROVENT (8 wks), then ADVAIR or SEREVENT (16 wks). ADVAIR
and SEREVENT are FDA approved for the treatment of asthma in patients 4 years of age and
older.

A Randomized, Parallel Group, Double-Blind, Comparative Trial Assessing Lung Function and
Other Measures of Asthma Control in Adults and Adolescents, at least 12 Years of Age, with
Persistent Asthma, Who Have Either a B16-Arg/Arg, a B16-Gly/Gly or a B-16 Arg/Gly Genotype
and are Treated With Fluticasone Propionate/Salmeterol DISKUS™ Combination Product 100/50mcg
or Salmeterol DISKUS 50 mcg BID

Inclusion criteria:

- Diagnosis of persistent asthma for 3 months.

- Use of short-acting beta-agonist medication like VENTOLIN.

Exclusion criteria:

- Hospitalization for asthma 6 months before study.

- Other serious diseases like congestive heart failure, uncontrolled hypertension, TB.

- Current use of inhaled or oral corticosteroids.
We found this trial at
74
sites
GSK Investigational Site
Bellingham, Washington 98225
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Asheville, North Carolina 28803
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Atlanta, Georgia 30341
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Atlanta, GA
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Baltimore, Maryland 21201
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Baltimore, MD
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Bayshore, New York 11706
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Bayshore, NY
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Boston, Massachusetts 02115
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Boston, MA
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Charleston, South Carolina 29425
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Charleston, SC
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Chattanooga, Tennessee 37421
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Chattanooga, TN
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Chicago, Illinois 60611
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Chicago, IL
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Colorado Springs, Colorado 80910
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Colorado Springs, CO
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GSK Investigational Site
Columbia, Missouri 65201
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Columbia, MO
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Coral Gables, Florida 33134
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Coral Gables, FL
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Corsicana, Texas 75110
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Corsicana, TX
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GSK Investigational Site
Covington, Louisiana 70433
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Covington, LA
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GSK Investigational Site
Dallas, Texas 75230
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Dallas, TX
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GSK Investigational Site
Denver, Colorado 80206
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Denver, CO
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GSK Investigational Site
El Paso, Texas 79915
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El Paso, TX
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Fort Worth, Texas 76104
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Fresno, California 93720
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Fresno, CA
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GSK Investigational Site
Fullerton, California 92835
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Fullerton, CA
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Hackensack, New Jersey 07601
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Hackensack, NJ
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Houston, Texas 77030
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Houston, TX
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Huntington Beach, California 92647
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Indianapolis, Indiana 46202
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Indianapolis, IN
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Inglewood, California 90301
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Inglewood, CA
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Irvine, California 92697
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Irvine, CA
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Jackson, Mississippi 39202
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Jackson, MS
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Jacksonville, Florida 32207
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Jacksonville, FL
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Kerrville, Texas 78028
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Kerrville, TX
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Kirkland, Washington 98034
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Kirkland, WA
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Knoxville, Tennessee 37916
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Knoxville, TN
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Lakewood, Colorado 80228
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Lakewood, CO
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Lawrenceville, Georgia 30046
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Lawrenceville, GA
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GSK Investigational Site
Lilburn, Georgia 30047
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Lilburn, GA
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GSK Investigational Site
Little Rock, Arkansas 72205
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Little Rock, AR
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Long Beach, California 90813
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Long Beach, CA
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Los Angeles, California 90025
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Los Angeles, CA
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Madison, Wisconsin 53792
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Madison, WI
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Medford, Oregon 97504
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Medford, OR
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Metairie, Louisiana 70006
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Metairie, LA
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Miami, Florida 33136
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Miami, FL
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Milwaukee, Wisconsin 53215
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Milwaukee, WI
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Mobile, Alabama 36617
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Mobile, AL
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Nairobi, 00200
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Nairobi,
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Nashville, Tennessee 37203
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New York, New York 10032
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GSK Investigational Site
Newark, New Jersey 07112
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Newark, NJ
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North Dartmouth, Massachusetts 02747
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Oklahoma City, Oklahoma 73112
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Oklahoma City, OK
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Orange, California 92868
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Orangeburg, South Carolina 29118
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Orlando, Florida 32806
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Overland Park, Kansas 66210
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Papillion, Nebraska 68046
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Philadelphia, Pennsylvania 19104
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Philadelphia, PA
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Richmond, Virginia 23298
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Richmond, VA
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Rochester, New York 14642
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Rochester, NY
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San Antonio, Texas 78258
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Sarasota, Florida 34232
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Shreveport, Louisiana 71103
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South Burlington, Vermont 05403
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South Miami, Florida 33143
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South Miami, FL
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Spartanburg, South Carolina 29303
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Spring Valley, California 91978
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St. Louis, Missouri 63110
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Stockton, California 95207
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Tallahassee, Florida 32308
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Tampa, Florida 33612
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Upland, Pennsylvania 19013
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Upland, PA
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Warrensburg, Missouri 64093
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Warrensburg, MO
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Waterbury, Connecticut 06708
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Waterbury, CT
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West Allis, Wisconsin 53227
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West Allis, WI
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Wheat Ridge, Colorado 80033
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Winston-Salem, North Carolina 27103
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