Evaluation of the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After Hysterectomy
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Women's Studies, Urology, Urinary Tract Infections |
| Therapuetic Areas: | Immunology / Infectious Diseases, Nephrology / Urology, Other, Reproductive |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 8/18/2018 |
| Start Date: | February 2016 |
| End Date: | July 30, 2018 |
Evaluation of Vaginal and Urinary Microbiome Markers as Predictors of Post-Surgical Urinary Tract Infection
The purpose of this study is to learn more about the microbes (bacteria) that live in the
vagina and the bladder. The investigators are doing this research study to understand the
relationship between microbes (the microbiome) and the occurrence of urinary tract infection
following surgical removal of the uterus and pelvic organ prolapse repair. The investigators
expect Lactobacillus and Gardnerella will be the dominant organisms for most women.
Non-Lactobacillus dominant microbiome communities will be more common in women who ultimately
develop postoperative urinary tract infection.
vagina and the bladder. The investigators are doing this research study to understand the
relationship between microbes (the microbiome) and the occurrence of urinary tract infection
following surgical removal of the uterus and pelvic organ prolapse repair. The investigators
expect Lactobacillus and Gardnerella will be the dominant organisms for most women.
Non-Lactobacillus dominant microbiome communities will be more common in women who ultimately
develop postoperative urinary tract infection.
The goal of this pilot study is to characterize the presence and stability of the microbial
community in the vagina and lower urinary tract in a cohort of 20 postmenopausal women
undergoing transvaginal hysterectomy with pelvic reconstruction for pelvic organ prolapse.
The investigators intend to collect longitudinal samples in the preoperative, intraoperative,
and postoperative time period in order to understand the pervasiveness of the microbes in the
vagina and lower urinary tract, and to identify, in a very preliminary way, particular
microbes that may be associated with postoperative urinary tract infection.
community in the vagina and lower urinary tract in a cohort of 20 postmenopausal women
undergoing transvaginal hysterectomy with pelvic reconstruction for pelvic organ prolapse.
The investigators intend to collect longitudinal samples in the preoperative, intraoperative,
and postoperative time period in order to understand the pervasiveness of the microbes in the
vagina and lower urinary tract, and to identify, in a very preliminary way, particular
microbes that may be associated with postoperative urinary tract infection.
Inclusion Criteria:
- Postmenopausal females (defined by cessation of menses for one full year)
- Planned surgical correction of pelvic organ prolapse with transvaginal hysterectomy
and concomitant pelvic reconstruction for uterovaginal prolapse
- Scheduled surgery date within 4 weeks of study consent
- Physically able to self-collect vaginal swabs and clean-catch urine samples
Exclusion Criteria:
- Women who are premenopausal, pregnant or nursing
- Currently taking or have taken antibiotics in the past 2 weeks
- History of recurrent urinary tract infections
- History of mesh complications, including erosion/extrusion
- Non-vaginal approach to hysterectomy or prolapse repair
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