A Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of BITS7201A in Healthy Volunteers and Participants With Mild Atopic Asthma

Inclusion Criteria:

General Inclusion Criteria:

- Body mass index between 18 and 37 kilograms per meter square (kg/m^2)

- Weight 50-120 kilograms

- Participants in good health, determined by no clinically significant findings from
medical history, 12-lead electrocardiogram (ECG), and vital signs

- Clinical laboratory evaluations should be within the reference range for the test
laboratory unless deemed not clinically significant by the Investigator and Sponsor.

- For women of childbearing potential: agreement to remain abstinent (refrain from
heterosexual intercourse) or use a highly effective contraceptive method for at least
70 days after the last dose of study drug

- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use
contraceptive measures, and agreement to refrain from donating sperm for at least 70
days after the last dose of study drug

Additional Inclusion Criteria for Participants With Mild Atopic Asthma:

- Diagnosis of asthma for greater than or equal to (>/=) 3 months prior to screening

- History of atopy

- Pre-bronchodilator forced expiratory volume in 1 second (FEV1) >/=60 percent (%)
predicted at screening

- Fractional exhaled nitric oxide (FeNO) >/=30 parts per billion (ppb) at screening and
at randomization (predose)

Exclusion Criteria:

General Exclusion Criteria:

- History or clinical manifestations of significant metabolic, hepatic, renal,
pulmonary, cardiovascular, gastrointestinal, urologic, neurologic, or psychiatric
disorders

- History of hematologic or immunosuppressive disorders

- History of severe depression or suicidal ideation

- History of inflammatory bowel disease

- History of anaphylaxis, hypersensitivity, or significant drug allergies

- History or presence of an abnormal ECG, which is clinically significant

- History of a positive tuberculin skin test in participants who are Bacille
Calmette-Guérin (BCG) vaccine naïve or history of a positive interferon-gamma release
assay in participants who have received the BCG vaccine

- Participants with neutropenia or thrombocytopenia

- History of alcoholism or drug addiction within 1 year of screening

- Self-reported history of smoking (tobacco, marijuana, or vaping) within the 7 days
prior to initiation of study drug

- Smokers not able to pass the tobacco-related laboratory screening and who cannot
refrain from smoking during the confinement periods

- Pregnancy or lactation

- History of malignancy, except completely excised basal cell carcinoma or squamous cell
carcinoma of the skin

- Any severe bacterial, fungal, or parasitic infections associated with hospitalization
or IV antibiotics within 1 year of screening

- History of active parasitic infection within 6 months or exposure to water-born
parasites within 6 weeks prior to initiation of study drug

- Upper or lower respiratory tract infection within 4 weeks prior to screening

- Received oral antibiotics within 4 weeks prior to initiation of study drug, or
IV/intramuscular (IM) antibiotics within 8 weeks prior to initiation of study drug

- For health volunteers: use of any prescription medications/products within 7 days
prior to Day 1 and throughout the study

- Use of any immunosuppressive medication within 30 days or 5 half-lives, whichever is
greater, prior to initiation of study drug

- Use of a non-biologic investigational drug or participation in an investigational
study with a non-biologic drug within 30 days prior to initiation of study drug (or
within 5 half-lives of the investigational product, whichever is greater)

- Use of a biologic investigational therapy or participation in an investigational study
involving biologic therapy within 3 months or 5 half-lives, whichever is greater,
prior to initiation of study drug

- Received live or attenuated vaccine within 30 days prior to screening

- Received killed vaccine within 14 days prior to initiation of study drug, unless
deemed acceptable by the investigator and Sponsor

- Positive blood test for chronic viral infections by: hepatitis B surface antigen,
hepatitis C virus antibody, or human immunodeficiency virus (HIV) antibody

Additional Exclusion Criteria for Participants With Mild Atopic Asthma:

- Poorly controlled asthma

- Use of any prescription medications and/or products other than asthma and/or allergic
rhinitis medications within 7 days prior to Day 1 and throughout the study, unless
deemed acceptable by the investigator and Sponsor

- Active lung disease other than asthma

- Occupations with potential exposure to exogenous sources of nitrous oxide and/or
associated with elevated FeNO

- Unable to perform FeNO measurement